Phenotype and pathology of the dilated cardiomyopathy with ataxia syndrome in children.

The dilated cardiomyopathy with ataxia syndrome (DCMA) is an autosomal recessive mitochondrial disease caused by mutations in the DnaJ heat shock protein family (Hsp40) member C19 (DNAJC19) gene. DCMA or 3-methylglutaconic aciduria type V is globally rare, but the largest number of patients in the world is found in the Hutterite population of southern Alberta in Canada. We provide an update on phenotypic findings, natural history, pathological findings, and our clinical experience.

[The influence of general magnetic therapy on the psychological status of the patients presenting with osteoarthrosis].

The present study was designed to estimate the influence of general magnetic therapy on the psychical conditions of 151 patients presenting with degenerative joint diseases including osteoarthritis (OA). It was shown that the application of general magnetic therapy for the rehabilitative treatment of osteoarthrosis promotes the improvement of the psycho-emotional state of the patients. It is concluded that prescription of general magnetic therapy to the patients with OA suffering from serious psycho-emotional disorders brings about beneficial changes in their anxiety- and depression-related personality traits.

[Influence of pancreatic segment graft autotransplantation on its exocrine function].

In experiments on dogs the exocrine secretion of pancreatic segment graft after its autotransplantation and of pancreatic stamps after proximal resection of the pancreas was investigated. More significant impairment of the exocrine secretion of the pancreas was revealed in animals after pancreatic graft autotransplantation in comparison with animals after the proximal resection of the pancreas. Maintenance of the adaptation of pancreatic exocrine secretion to the nutritional composition of the intestinal contents and "generalized inhibition" of pancreatic exocrine secretion caused by duodenal trypsin infusion was revealed in all groups.

[The mechanical models of the physiology of teeth].

Based on the universal laws of mechanics and physical chemistry, physiology build mechanical models of teeth, which allowed to explain the role of mastication in the mechanism of demineralization and remineralization of hard tissues of teeth and asymmetry of erasing their working surfaces. In the process of chewing capillary and baric effects contribute to changes in calcium and phosphorus on the working side of the tooth, reaching 30% for any chemical composition of food. Erasing the working surfaces of lower teeth contributes to their specific role in the mechanical and chemical mechanisms of degradation of food due to the mobility of the mandible.

[Interrelation between personal characteristics of students and the successfulness of their training].

The main individual and typological personality characteristics of 246 female and 120 male students were determined with psychological tests. The results were compared to the measure of the successfulness of their training, determined as the mean score of the three last exam sessions. In both groups, failure-avoidance motivation dominated in 62% of students, while success-achievement motivation dominated in 37% of students.

[Problems in the identification and recording of patients with tuberculosis in investigatory solitary cells].

The analysis of the results of the detection, diagnosis, and recording of patients with active tuberculosis in an investigatory solitary cells of the Department of Penitentiary Facilities, Ministry of Justice of the Republic of Moldova, has revealed significant features that greatly differ not only from such a direction of work in the health care facilities, but also from other institutions (penal colonies, settlements) of this system. These features are associated with the specificity of the working conditions of investigatory solitary cells and mainly with the constant change of this contingent.

[The dynamics of pain perception under conditions of goal-directed activities].

The dynamics of nociception was studied in young male volunteer students with different indices of extraversion and neurotism under conditions of their relative psychoemotional rests and psychoemotional tension induced by academic exams and blood-donation procedures. The averaged somatosensory potentials evoked by threshold electrodermal pain stimuli were recorded in the state of rest and during performance of computer-adapted proof-reading test. In ambivalent, sanguine, choleric, and phlegmatic persons the mean values of nociception thresholds differed between testing situations and rest.

[Potentialities of lymphography using chromethiotrast, a new x-ray contrast medium].

A study was made of the potentialities of lymphography using a new radiopaque medium chromethiotrast (a solution of harmless fat-soluble anthraquinone dyes fixed with ethiotrast). The agent is intended for combined x-ray and visual investigation of the lymphatic system. Lymphograms of 76 patients (with Hodgkin's disease, prostatic cancer, cancer of the female organs, breast, bladder, rectal cancer, and secondary limb lymphedema) were analyzed.

[Population migration and tuberculosis].

Characteristic features of a migratory process of tuberculosis patients in the Republic of Moldova were subjected to study. Two tendencies have been revealed: growth of a number of the arriving subjects and deterioration of the structure of pulmonary tuberculosis among them. Patients who arrived from the places of confinement where morbidity persists on a high level constitute a particular hazard concerning tuberculosis dissemination.

[Schemes for implanting shovel pumps for assisted circulation].

The authors propose a design of an axial shovel pump for extracorporeal circulation. They show how to introduce it into various cardiovascular segments and make a comparative assessment of its efficacy in relation to the type and severity of heart failure, surgical access, and treatment policy.

[Use of the automated system of information processing in tuberculosis control].

A notification variant has been designed on the basis of the No. 089 form "Notification of a patient with newly diagnosed active tuberculosis", which is used for information feeding into computer on persons with newly diagnosed tuberculosis and on those registered in a dispensary; it is also used as a corrective coupon. The automated system for information processing "Tuberculosis" has been developed which allows a centralized control over the early detection and dispensarization of patients, efficient assessment of the accumulated information and proper decision making.

[New pneumatic and hydraulic devices for assisted and artificial circulation (a hybrid artificial heart)].

The authors offer a system for auxiliary circulation (a "hybrid man-made heart"), review design varieties, describe the functioning of the system. The paper is of interest for designers of the systems for extracorporeal circulation and for practicing physicians concerned with the problems of cardiology.

[Organization of BCG revaccination of young adults].

For the purpose of BCG revaccination of the young people (aged 13-30 years) having a negative tuberculin response, 3 methods of vaccination were practised, including working as a team, launching an expedition and functioning within a residential area. The choice of the method required is dictated by the local conditions and the given task. A high level of tuberculosis infection was recorded, especially among the risk groups in relation to this disease.

[Functional status of the hepatobiliary system during anti-orthostatic hypodynamia].

In 16 male subjects, the hepatic absorption-excretion function and the gallbladder and biliary ducts were investigated using computer scintigraphy and 99mTs-HIDA. Comparison of the data obtained after 6-hour (-20 degrees) and 3-day (10 degrees) antiorthostatic hypodynamics with the baseline data obtained in the supine position demonstrated deterioration of the absorption-excretion function of the liver. In response to a short-term exposure (6 hour) the changes were seen only in subjects with latent or clinically nonmanifest pathologies of the digestive organs.

[Contrast media: present status and future of their production and use].

Analysis of the problems involving the design and application of Soviet-made radiocontrast agents showed that the synthesis of such drugs as Iodamid, Triombrast, Etiotrast, Bilimin, and Bilignost in this country made it possible to eliminate the arrears in this field. Together with the elaboration of topics concerning the pharmacokinetics and adverse effects of the above contrast agents, this helped to create a sound scientific base for further work on the unsolved problems, primarily, (1) to synthesize Soviet non-ionogenic radiocontrast agents; (2) to prepare and introduce Soviet ultrasonographic contrast agents into practice; (3) to prepare and introduce magnetic resonance contrast ones into practice; and (4) to introduce unique radiocontrast agents such as triombrast as oil emulsion, oleoferrotrast, fine-dispersion barium sulphate, and chromoetiotrast into clinical practice and to set up their production.

[Role of tests of the total pressure of gases (O2 and CO2) in blood plasma in studying gaseous homeostasis in man].

Sixty essentially healthy subjects were examined manometrically with blood withdrawn from the coronary sinus, pulmonary artery, aorta, veins of the right kidney and the right liver lobe. Together with the traditional parameters of the gas contents and gradients of plasma, it is proposed to use tests measuring additive O2 and CO2 parameters. It has been demonstrated that the above organs can be discriminated using tests that are additive with respect to the gas pressure.

[Dynamics of the redistribution of human blood in response to lower body negative pressure].

During exposure to LBNP of -10 to -60 mm Hg variations in the blood filling of body segments were measured, using 59Fe labelled erythrocytes. The study was performed on 10 healthy volunteers each of which was exposed to six LBNP sessions (in recumbency). The data obtained were related to changes in the blood filling of various body segments (head, thorax, abdomen, pelvis, legs) which were most pronounced at LBNP -20 to -30 mm Hg.

[Late radiation injuries of lungs after combined therapy in breast cancer].

The paper is concerned with the results of examination and treatment of 140 patients with late radiation injuries of the lungs developing in a late period after combined treatment (operation + radiotherapy) of breast cancer. The sooner the treatment was initiated, the more effective it was.

[Interpretation of the kinetocardiogram of the right heart].

On the basis of ultrasonic Doppler valvulocardiography of 20 healthy men and catheterization of the right heart of 15 patients with acute large-focal myocardial infarction, the development of elements of the right kinetocardiograms (KCGr) is explored. Comparison of kinetocardiograms of the right heart with ultrasonic and catheterization data has demonstrated that KCGr can be used to examine right heart contractions of cosmonauts and pilots in flight and on the ground as well as of patients to diagnose pathologies of the right compartments of the heart.