[Effect of actinomycin D on salinity acclimation of Paramecium calkinsi (Ciliophora, Peniculia)].

Salinity acclimation of euryhaline ciliate Paramecium calkinsi evaluated by swimming velocity was over in 4-5 days. In two series of the main experiment, the acclimation was over in two and three days when actinomycin D (an inhibitor of DNA-dependent RNA polymerase) was added after various periods of the ciliate incubation at a changed salinity (0, 3, 6, and 24 h). The obtained data indicate that the inhibiting effect of actinomycin D on salinity acclimation of P.

[The effect of cholisorb on liver exocrine function].

The effect of cholisorb and its salt (Na and K) forms on the external secretion of the liver was studied. The cholagogic effect of the H-form of cholisorb and its salt forms was demonstrated in dog experiments. The effect of the H-form proved to be stronger.

[The kinetics of the excretion of a choline-containing polymer from the body of rats and its effect on the activity of intestinal enzymes].

It was shown that the studied choline-containing polymer is practically not absorbed in the gastrointestinal tract. It is eliminated mainly on the first day. It causes an inhibitory effect on disaccharidases, does not affect animal growth, and has no negative effect on food uptake.

[A deficient T-cell count and its elimination during the treatment and prevention of infections].

The results of the study of the parameters of the immune system in persons suffering from frequent infections, bacteriocarriers and persons with nonspecific infections are presented. The study revealed that T-cell deficiency of the 2nd and 3rd degrees could be regarded as the universal marker of decreased immune reactiveness. Sodium nucleinate was found to be capable of stimulating the T-cell element of immunity and antibody formation, which made it possible to achieve a considerable decrease in morbidity rate.

[Directed cleavage of the 16S rRNA molecule at a single internucleotide bond].

Cleavage of 16S ribosomal RNA (rRNA) from E. coli "hammerhead" type ribozymes as well as by RNAase iI in the presence of "hymeric" (2'-deoxy-F-thymidine containing) oligonucleotides has been studied. The conditions for the cleavage of a desired single internucleotide bond have been found for a large molecule with a very complicated secondary and three-dimensional structure.

[The prospects for using inactivated influenza vaccines on the troops].

The article analyses the results of controlled epidemiologic observation made in military unit to estimate the immunological and clinico-epidemiological efficiency of national inactivated influenza vaccines with different valency and antigen charge in inoculative dose. The analysis proves the high immunogenic activity and protective features of inactivated influenza trivaccines with enhanced contents of hemagglutinins. The article substantiates the reasons for mass application of these vaccines in military units with obligatory addition of B-component and enhanced antigen contents of vaccine viruses in inoculative dose.

[The clinico-epidemiological efficacy of thymogen in acute respiratory viral infections in a military collective].

This study gathers the results of epidemiological examination in training military unit, making evaluation of prophylactic efficiency of timogen, i.e. synthetic peptide of thymus for flu and other acute respiratory infections (ARI).

[Body immunocorrection when vaccination is contraindicated (a clinico-epidemiological validation)].

The article summarizes the results of epidemiological observation which was performed in one of the training units. The goals of this observation were to estimate the prophylactic efficiency of the selected application of Natrii nucleinas in persons with the lowered immunoresistance on the background of antigrip immunization. A high clinico-epidemiological effectiveness ws approved for 10-days administration of the Natrii nucleinas in persons with clinic manifestations of grip and other respiratory infections at the moment of vaccination.

[The surgical treatment of acute cholecystitis in patients in a group at increased risk].

The article deals with the results of treatment of acute cholecystitis in 190 patients of the increased risk group. An urgent operation was performed on 25 patients, the others received intensive nonoperative treatment and were subjected to complex examination aimed primarily at assessing the hepatic function (ultrasonic examination with photometric determination of screen luminescent brightness, intraduodenal contact electrothermometry, plasma biochemical tests). In failure of this treatment 88 patients underwent transhepatic microcholecystomy, one-stage external-internal drainage was carried out in 43 patients.

[The current possibilities for optimizing the diagnosis of acute cholecystitis].

Based on an analysis of the material of clinical observations of 1523 patients with acute cholecystitis the authors make a conclusion that findings of repeated echosonography with photometry and endoscopic intraduodenal electrothermometry of the duodenal mucosa allow reliable diagnosis of acute cholecystitis, estimation of the character of morphological alterations of the gallbladder wall, determination of the morphofunctional state of the liver. These methods allow to reliably control the course of the inflammatory process in acute cholecystitis and to timely change the curative tactics.

[Changes in the etiologic structure of Sonne shigellosis in its multiyear dynamics].

The dynamics of Sonne dysentery morbidity in connection with changes in the structure of S. sonnei circulating among the population of Leningrad for the period of 1959-1984 was studied. Considering such sign as the leading fermentovar, three smaller periods were established in this stretch of time.

[Manifestations of genotypic and phenotypic heterogeneity in populations of Shigella sonnei and of humans at different phases of the development of the epidemic process].

The study of the structure and developmental dynamics of S. sonnei populations and the state of local immunity to this infection in children under school age has revealed that the interaction of the heterogeneous populations of the parasite and the host is the internal motive force of the self-regulating phasic development of the epidemic process. In the course of this process complementary changes in the virulence of the infective agent and in the immunoresistance of children are generated on the basis of negative feed-back.

[Intracellular neutralization of bacteriophage T4 by antiphagic serum].

Specific antiserum, introduced into the spheroplasts of Escherichia coli B infected with bacteriophage T4, has been shown to neutralize phage particles formed within the cells.