Multi-functional PEEK implants enhance osseointegration in OVX rat by remodeling the bone immune microenvironment.

Osseointegration is significantly impeded in osteoporotic conditions due to the elevated levels of reactive oxygen species (ROS) and inflammation at the site of injury. To enhance bone regeneration in osteoporotic conditions, a modified polyether ether ketone (PEEK) implants was prepared, denoted as PEEK-PDA-Sr. The implants consisted of mussel adhesion layer with the conjugation of strontium (Sr) ions, which can constantly release Sr ions for up to 3 weeks.

A dual-functional strontium-decorated titanium implants that guides the immune response for osseointegration of osteoporotic rats.

Due to the dynamic imbalance between osteogenesis and osteoclasis and the abnormal inflammatory microenvironment in situ, osteoporosis hampers the early osseointegration between implants and bones. To improve osseointegration with the osteoporosis, we first coated the titanium implants (Ti) with polydopamine (PDA) coating (Ti-PDA), followed by modification with strontium (Sr) to prepare the Ti-PDA-Sr implants. An osteoporotic rat model with femoral bone defect was verified to estimate the osseointegration of the implants.

Bi-functional titanium-polydopamine-zinc coatings for infection inhibition and enhanced osseointegration.

The ideal orthopedic implant coating is expected to both inhibit microbial infection and promote osseointegration. In this study, Zn ions were immobilized on a Ti substrate a polydopamine (PDA) chemical surface modification to prepare Ti-PDA-Zn coatings. Scanning electron microscopy (SEM), atomic force microscopy (AFM), energy-dispersive X-ray spectroscope (EDS), X-ray photoelectron spectroscopy (XPS), contact analysis system, and inductively coupled plasma atomic emission spectrometry (ICP-AES) were used to analyze the morphology, composition, wettability, and zinc ions release of the coatings.

PPAR-α Agonist WY-14643 Inhibits LPS-Induced Inflammation in Synovial Fibroblasts via NF-kB Pathway.

Osteoarthritis (OA), the most prevalent form of arthritis that results from breakdown of joint cartilage and underlying bone, has been viewed as a chronic condition manifested by persistence of inflammatory responses and infiltration of lymphocytes. Regulation of the inflammatory responses in synovial fibroblasts might be useful to prevent the development and deterioration of osteoarthritis. WY-14643, a potent peroxisome proliferator activator receptor-α (PPAR-α) agonist, has been described to beneficially regulate inflammation in many mammalian cells.

Comparative study of InterTAN and Dynamic Hip Screw in treatment of femoral intertrochanteric injury and wound.

The aim of this study is to compare the effects and complications of InterTAN nail versus Dynamic Hip Screw (DHS) in treatment of femoral intertrochanteric fractures. Between January 2006 and December 2013, a total of 75 patients with femoral intertrochanteric fractures were retrospectively reviewed. There were 16 cases of type A1, 51 cases of type A2, and 8 cases of type A3.

[Establishment of an in vitro model of natural degeneration of lumbar endplate chondrocytes and expression of Sox9 therein].

Objective: To establish an in vitro model of natural degeneration of lumbar endplate chondrocytes and explore the role and the expression change of Sox9 gene, an important gene in the differentiation and maturation of chondrocyte, in the process of natural degeneration of endplate chondrocytes.

Methods: The lumbar vertebrae of 35 SD rats were taken out to obtain the endplates. Endplate chondrocytes were isolated by enzyme digestion and cultured so as to establish an in vitro natural degeneration model of chondrocytes.