Publications by authors named "Degang Guo"
MiR-199 Aggravates Doxorubicin-Induced Cardiotoxicity by Targeting TAF9b.
Evid Based Complement Alternat Med
July 2022
The clinical application of doxorubicin (DOX) is limited because of its cardiotoxicity. However, the pathogenic mechanism of DOX and the role of miRNA in DOX-induced cardiotoxicity remain to be further studied. This study aimed to investigate the role of miR-199 in DOX-mediated cardiotoxicity.
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- Light perception in fungi activates the HOG pathway, potentially boosting stress response genes, suggesting that controlling light conditions can enhance conidial production and stress resilience in biocontrol agents and biofertilizers.
- The study examined how different light wavelengths and intensities affect conidial yield and resistance to various stresses.
- Blue light at 2 μmol photons/(m × s) significantly increased conidial yield over 1000 times compared to darkness, while also enhancing stress resistance, linked to the activity of stress-related genes regulated by the receptor BLR1 and MAP kinase HOG1.
Conidia of Trichoderma guizhouense (Hypocreales, Ascomycota) are frequently applied to the production of biofertilizers and biocontrol agents. Conidiation of some Trichoderma species depends on blue light and the action of different blue light receptors. However, the interplay between different blue-light receptors in light signalling remained elusive.
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