A Sensitive Electrochemiluminescence Urea Sensor for Dynamic Monitoring of Urea Transport in Living Cells.

A multiple signal-amplified electrochemiluminescence (ECL) urea sensor was designed based on a self-enhanced probe and SiO photonic crystals for dynamic tracking of urea transmembrane transport. The self-enhanced probe (AuNR@Ru-LA) prepared by loading polyethyleneimine (PEI), lactobionic acid (LA), and Ru(dcbpy) on gold nanorods (AuNRs) generated an initial ECL signal, and then the intensity was multiple-amplified by the enhanced light-scattering effect of SiO photonic crystals and the co-reaction with urea. The as-prepared sensor exhibited excellent performance for the detection of urea in the range of 1.

Ratiometric ECL sensor based on Apt-AuNS@Lu nanoprobe for analyzing cell swelling-induced ATP release.

A novel ratiometric electrochemiluminescence (ECL) system based on gold nanostars (AuNSs) support was constructed for the determination of hypotonicity-induced ATP release from HepG2 cells. AuNS@Lu nanoprobe was used as anodic luminophore and KSO as cathodic luminophore as well as anodic co-reactant. AuNS with the large specific surface was adopted to adsorb plentiful luminol to form solid-state probe and as affinity support to immobilize ATP aptamer (Apt).

A novel signal amplified electrochemiluminescence biosensor based on MIL-53(Al)@CdS QDs and SiO@AuNPs for trichlorfon detection.

An ultrasensitive electrochemiluminescence (ECL) biosensor was developed based on MIL-53(Al)@CdS QDs and SiO@AuNPs for trichlorfon detection. Metal-organic frameworks (MOFs) were used as a loading platform that provided a large surface area to load targets and modified materials onto the electrode. At the same time, SiO@AuNPs loaded plenty of AuNPs which effectively increased the ECL resonance energy transfer between the CdS QDs, so that the ECL signal was strongly quenched and resulted in an amplified response.

A photoelectrochemical aptasensor for the sensitive detection of streptomycin based on a TiO/BiOI/BiOBr heterostructure.

In photoelectrochemical sensor (PEC sensor), sensitivity and selectivity are two essential factors which are determined by photosensitive of materials and identification of elements. Herein, a novel PEC aptamer sensor for streptomycin-specific detection was developed, with which the visible-light-active TiO/BiOI/BiOBr heterostructure and aptamers were employed as photoactive material and bio-identification elements, separately. The combination of an appropriate amount of TiO with BiOI/BiOBr enhanced the photocurrent response, and thus is beneficial to the construction of PEC sensors.

Electrochemiluminescence aptasensor for multiple determination of Hg and Pb ions by using the MIL-53(Al)@CdTe-PEI modified electrode.

An aptasensor based on MIL-53(Al)@CdTe was designed for multiple determination of Hg and Pb by electrochemiluminescence (ECL). Upon the recognition of Hg, aptamer 2-AuNPs form hairpin structures and are removed from the electrode. While in the presence of Pb, aptamer 1-PtNPs capture the target ions and form G-quadruplexes, and then bring PtNPs close enough to CdTe QDs to produce ECL resonance energy transfer.

Electrochemiluminecence nanogears aptasensor based on MIL-53(Fe)@CdS for multiplexed detection of kanamycin and neomycin.

A dual gears electrochemiluminecence (ECL) aptasensing strategy for multiple selective determination of kanamycin and neocycin was designed on the basis of the combination of kanamycin and neocycin induced dual gears conversion, the loading platform of metal-organic frameworks (MOFs), surface plasmon resonance (SPR) and ECL resonance energy transfer (ERET) between CdS QDs and AuNPs (or PtNPs). In the absence of target, the dual gears were "off". Then the B1-AuNP (gear B) and aptamer 1-PtNPs acted as signal quenching elements to quench ECL intensity due to ERET process.

Ru(bpy)-Silica@Poly-L-lysine-Au as labels for electrochemiluminescence lysozyme aptasensor based on 3D graphene.

In this work, the feasibility of a novel sensitive electrochemiluminescence aptasensor for the detection of lysozyme using Ru(bpy)-Silica@Poly-L-lysine-Au (RuSiNPs@PLL-Au) nanocomposites labeling as an indicator was demonstrated. The substrate electrode of the aptasensor was prepared by depositing gold nanoparticles (AuNPs) on 3D graphene-modified electrode. The lysozyme binding aptamer (LBA) was attached to the 3D graphene/AuNPs electrode through gold-thiol affinity, hybridized with a complementary single-strand DNA (CDNA) of the lysozyme aptamer labeled by RuSiNPs@PLL-Au as an electrochemiluminescence intensity amplifier.