Publications by authors named "Deepti Jamwal"
Article Synopsis
- New variants of SARS-CoV-2 highlight the need for effective treatments, leading to the discovery of a powerful monoclonal antibody called P4A2 that neutralizes all current variants, including Omicron.!
- The structure of the P4A2 antibody reveals that its target on the virus's spike protein remains unchanged across different variants, ensuring its effectiveness against circulating strains.!
- Testing in mice shows that administering P4A2 can protect against infections from these variants, suggesting significant therapeutic potential for future SARS-CoV-2 variants as well.!
Article Synopsis
- * Binding studies indicate that II62 effectively interacts with various SARS-CoV-2 variants without disrupting the virus's ability to bind to the ACE2 receptor.
- * Neutralization tests show that increasing the antibody's valency from monovalent to tetravalent does not negatively affect its interaction with host cells in virus testing assays.
Phage display is a proven and widely used technology for selecting specific antibodies against desired targets. However, an immense amount of effort is required to identify and screen the desired positive clones from large and diverse combinatorial libraries. On the other hand, the selection of positive binding clones from synthetic and semi-synthetic libraries has an inherent bias toward clones with randomly produced amber stop codons, making it more difficult to identify desirable binding antibodies.
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