Publications by authors named "Deepthi Pasumarthi"
Article Synopsis
- Cervical cancer is a leading cause of death among women, especially in developing countries, and the role of the protein osteopontin (OPN) in its progression is being investigated.
- The study analyzed three microarray datasets to identify differentially expressed genes and performed enrichment and interaction network analyses to better understand the tumor microenvironment.
- Results indicated that OPN is significantly upregulated in cervical cancer, and the drug Entrectinib shows promise as a potential inhibitor to help combat the disease.
Cervical cancer is the second most common cause of cancer deaths in women worldwide and remains the main reason of mortality among women of reproductive age in developing countries. Nitric oxide is involved in several physiological functions inclusive of inflammatory and immune responses. However, the function of NO in tumor biology is debatable.
View Article and Find Full Text PDFCervical cancer is one of the most malignant reproductive diseases seen in women worldwide. The identification of dysregulated genes in clinical samples of cervical cancer may pave the way for development of better prognostic markers and therapeutic targets. To identify the dysregulated genes (DEGs), we have retrospectively collected 10 biopsies, seven from cervical cancer patients and three from normal subjects who underwent a hysterectomy.
View Article and Find Full Text PDFThis work is aimed at investigating the expression levels of inducible nitric oxide synthase (iNOS) in cervical cancer and identifying a potential iNOS inhibitor. The data mining studies performed advocated iNOS to be a promising biomarker for cancer prognosis, as it is highly overexpressed in several malignant cancers. The elevated iNOS was found to be associated with poor survival and increased tumor aggressiveness in cervical cancer.
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