A novel deep unsupervised approach for super-resolution of remote sensing hyperspectral image using gompertz-function convergence war accelerometric-optimization generative adversarial network (GF-CWAO-GAN).

Hyperspectral remote sensing images obtained from cameras are characterized by high-dimensions and low quality, which makes them unfavorable for various analytics purposes. This is due to the presence of visible and invisible frequencies of the reflected light making it poorly reveal the spectral signatures of the image. Visual communication advancement has paved the need for Image Super-Resolution (SR) which recovers high-resolution images from low-resolution images.

A deep drug prediction framework for viral infectious diseases using an optimizer-based ensemble of convolutional neural network: COVID-19 as a case study.

The SARS-CoV-2 outbreak highlights the persistent vulnerability of humanity to epidemics and emerging microbial threats, emphasizing the lack of time to develop disease-specific treatments. Therefore, it appears beneficial to utilize existing resources and therapies. Computational drug repositioning is an effective strategy that redirects authorized drugs to new therapeutic purposes.

Assessing Seminal Plasma Malondialdehyde Acid as a Diagnostic Tool for Male Infertility: A Case-Control Study.

Aim: The aim of this study was to assess the role of seminal Malondialdehyde Acid (MDA) in the diagnosis of male infertility.

Background: Both male and female infertility is increasing all over the world.

Objective: The purpose of this study was to assess the impact of seminal MDA levels on various semen parameters of healthy fertile men and men with infertility, and to know the efficacy of seminal MDA in the diagnosis of male infertility.

An ensemble approach for circular RNA-disease association prediction using variational autoencoder and genetic algorithm.

Circular RNAs (circRNAs) are endogenous non-coding RNAs with a covalently closed loop structure. They have many biological functions, mainly regulatory ones. They have been proven to modulate protein-coding genes in the human genome.

Knowledge and awareness of clinical trials among trial participants in India: A multicentric questionnaire-based cross-sectional study.

Purpose: The knowledge and attitude of participants toward clinical trials (CTs) are a key determinant in successful recruitment and retention. This study aimed to evaluate knowledge and awareness-attitude among the recruited CT participants about CTs.

Methods: This was a cross-sectional face-to-face survey comprising CT participants involved in the past or currently a part of a CT during this study within the Indian Ophthalmology Clinical Trial Network (IOCTN).

Attitude and perception toward clinical trials in India among patients and patient bystanders visiting the Indian Ophthalmology Clinical Trial Network: A multi-centric, cross-sectional survey.

Purpose: Advances in patient treatment depend heavily on clinical trials (CTs). Patient volunteers for CT are tougher to recruit and retain. In order to administer CTs effectively, it is necessary to comprehend how the public views and perceives participating in them.

Knowledge and perception of health-care professionals on clinical trials in India: A pan-Indian cross-sectional survey.

Purpose: The purpose of the study was to evaluate the knowledge and perception of health-care professionals (HCPs), such as doctors/surgeons, pharmacists, nurses, optometrists, and lab technicians, on clinical trials (CTs) in India.

Methods: The study was a pan-Indian cross-sectional survey initiated by the Indian Ophthalmology Clinical Trial Network (IOCTN) by using a previously validated questionnaire for three months of data collection. An online survey was used to record information regarding demographics, CT knowledge, and CT perception among HCPs.

Seminal plasma testis expressed sequence (TEX)-101 as a biomarker for the qualitative assessment of male factor infertility: A case-control study.

Objective: The study was conducted to assess the role of seminal plasma Testis Expressed Sequence (TEX)-101 as a biomarker of male infertility.

Study Design: The study was conducted on 180 men (20-50 years) with 90 having abnormal semen reports as cases and 90 with normal reports as controls in a rural tertiary care center in Southern India over two years. After the enrolment of cases and control, semen samples were cryopreserved till the desired sample size was achieved and a biochemical test for TEX-101 was run using Human Testis-expressed Protein 101 ELISA Kit.

Whole genome sequence data of TBG-201, a chitinolytic actinomycete isolated from the Vandanam sacred groves of Alleppey District, Kerala, India.

This study presents the complete genome sequence of TBG-201 isolated from the soil samples of Vandanam sacred groves in Alleppey District, Kerala, India. The organism has potent chitinolytic activity. The genome of TBG-201 was sequenced using the Illumina HiSeq-2500 platform with 2 × 150bp pair-end protocol and assembled using Velvet version 1.

A deep learning ensemble approach to prioritize antiviral drugs against novel coronavirus SARS-CoV-2 for COVID-19 drug repurposing.

The alarming pandemic situation of Coronavirus infectious disease COVID-19, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a critical threat to public health. The unexpected outbreak and unrealistic progression of COVID-19 have generated an utmost need to realize promising therapeutic strategies to fight the pandemic. Drug repurposing-an efficient drug discovery technique from approved drugs is an emerging tactic to face the immediate global challenge.

Native Wolbachia influence bacterial composition in the major vector mosquito Aedes aegypti.

Bacterial species that inhabit mosquito microbiota play an essential role in determining vector competence. In addition to critical factors such as host genotype, feeding habit and geography, intracellular endosymbiont Wolbachia pipientis modulates microbial composition considerably. In the present study, we assessed the midgut bacterial diversity of Aedes aegypti mosquitoes that is either naturally carrying Wolbachia (wAegB) or antibiotic cured (wAegB) through a culture-independent approach.

A Case of Neonatal Diabetes Mellitus Due to Gene Mutation with Maternal Mosaicism and Atypical Presentation.

Neonatal diabetes mellitus is a single gene defect that results in diabetes mellitus in the first 6 months of life. We report a child who was diagnosed to be hyperglycemic at 13 months of life and assumed to have type 1 diabetes mellitus and started on insulin. The child came to us at 2 and 1/2 years of age.

Neuropsychological performance in youth with obsessive-compulsive disorder.

There is a paucity of literature on neuropsychological functions in youth with obsessive-compulsive disorder (OCD). Most studies have small sample sizes and have yielded inconsistent results. A recent meta-analysis failed to identify any significant impairments.

Assessment of the viability of human periodontal ligament cells in black tea, lime juice, and passion fruit concentrate - A comparative study.

Background: Tooth avulsion is considered as a severe form of dental trauma, causing damage to the periodontium. Hence, the preservation of healthy periodontal ligament (PDL) cells in the storage medium are pivotal for the success of replantation.

Aim And Objective: The aim of this study is to assess the viability of human PDL cells in black tea, lime juice, and passion fruit concentrate.

Inferring Potential CircRNA-Disease Associations via Deep Autoencoder-Based Classification.

Aim: Circular RNAs (circRNA) are endogenous non-coding RNA molecules with a stable circular conformation. Growing evidence from recent experiments reveals that dysregulations and abnormal expressions of circRNAs are correlated with complex diseases. Therefore, identifying the causal circRNAs behind diseases is invaluable in explaining the disease pathogenesis.

An ensemble approach for CircRNA-disease association prediction based on autoencoder and deep neural network.

Circular RNAs (circRNA) are a special kind of covalently closed single-stranded RNA molecules. They have been shown to control and coordinate various biological processes. Recent researches show that circRNAs are closely associated with numerous chronic human diseases.

Co-assembly of functionalized donor-acceptor molecules within block copolymer microdomains via the supramolecular assembly approach with an improved charge carrier mobility.

Here, we demonstrate the three-component self-assembly of functionalized small molecules (donor and acceptor) and a polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) block copolymer using the supramolecular approach. The introduction of functional groups on both the donor (1-pyrenebutyric acid, PBA) and acceptor (functionalized naphthalene diimide, FNDI) molecules can form stable charge-transfer (CT) complexes within the block copolymer domains and these supramolecules exhibited a charge carrier mobility of around 1.01 × 10 cm (V s).

Drug repositioning based on the target microRNAs using bilateral-inductive matrix completion.

Identifying the cause-and-effect mechanism behind the drug-disease associations is a challenging task. Recent studies indicate that microRNAs (miRNAs) play critical roles in human diseases. Targeting specific miRNAs with drugs to treat diseases provides a new aspect for drug repositioning.

Ocular bacterial infections: Pathogenesis and diagnosis.

The human eye is a rigid asymmetric structure with unique defence system. Despite considerable resident microbiota, eye is exposed to external environment where a range of microorganisms also inhabits. Opportunistically, some of these microorganisms could associate with eye pathogen that could contact incidentally, leading to destructive visual consequences.

Lip repositioning, an alternative treatment of gummy smile - A case report.

The aim of present case report is to discuss surgical lip repositioning technique for the management of excessive gingival display related with vertical maxillary excess and increase mobility of the upper lip. By restricting the muscle pull by elevator lip muscles, this procedure reduces excessive gingival display during smiling. For patient, this procedure is safe, less invasive with minimal side effects and an alternative to orthognathic surgery in the correction of gummy smile.

Clinical profile and outcome in a large sample of children and adolescents with obsessive-compulsive disorder: A chart review from a tertiary care center in India.

Background: Obsessive-compulsive disorder (OCD) is a common psychiatric illness in children and adolescents. Till date, the sample sizes in the Indian studies have been relatively small.

Methodology: The present study is a retrospective chart review of a large sample of children and adolescents diagnosed with OCD in a tertiary care center.

Polybacterial community analysis in human conjunctiva through 16S rRNA gene libraries.

The conjunctival sac of healthy human harbours a variety of microorganisms. When the eye is compromised, an occasional inadvertent spread happens to the adjacent tissue, resulting in bacterial ocular infections. Microbiological investigation of the conjunctival swab is one of the broadly used modality to study the aetiological agent of conjunctiva.

Molecular diagnosis of Salmonella typhi and its virulence in suspected typhoid blood samples through nested multiplex PCR.

A nested multiplex polymerase chain reaction (PCR) based diagnosis was developed for the detection of virulent Salmonella typhi in the blood specimens from patients suspected for typhoid fever. After the Widal test, two pairs of primers were used for the detection of flagellin gene (fliC) of S. typhi.

First Measurement of Electron Neutrino Appearance in NOvA.

We report results from the first search for ν_{μ}→ν_{e} transitions by the NOvA experiment. In an exposure equivalent to 2.74×10^{20} protons on target in the upgraded NuMI beam at Fermilab, we observe 6 events in the Far Detector, compared to a background expectation of 0.

Mitochondrial antiviral-signalling protein plays an essential role in host immunity against human metapneumovirus.

Human metapneumovirus (hMPV) is a common cause of respiratory tract infection in the paediatrics population. Recently, we and others have shown that retinoic acid-inducible gene 1 (RIG-I)-like receptors (RLRs) are essential for hMPV-induced cellular antiviral signalling. However, the contribution of those receptors to host immunity against pulmonary hMPV infection is largely unexplored.