Publications by authors named "Deepsikha Kar"
Apart from the canonical fingers, palm and thumb domains, the RNA dependent RNA polymerases (RdRp) from the viral order Nidovirales possess two additional domains. Of these, the function of the Nidovirus RdRp associated nucleotidyl transferase domain (NiRAN) remains unanswered. The elucidation of the 3D structure of RdRp from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), provided the first ever insights into the domain organisation and possible functional characteristics of the NiRAN domain.
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- The COVID-19 outbreak has highlighted the need for new treatments, particularly targeting the virus's RNA-dependent RNA polymerase (RdRp).
- Using bioinformatics and computational modeling, researchers identified the 3D structure of RdRp and its GTP binding pocket, which is essential for RNA replication.
- By testing small molecule inhibitors designed for hepatitis C, they've refined their search and found a promising lead molecule that could serve as a strong candidate for combating SARS-CoV2.