Association of preoperative serum adipokines, insulin, and sex steroid hormones with breast cancer risk in the Indian women.

Background: Obesity-related factors such as adipokines, insulin, insulin-like growth factors, and sex steroid hormones have been reported to be involved in breast carcinogenesis. Studies across the world suggest an important, but still controversial, role of obesity in breast cancer risk. This study aims to evaluate the association of obesity-related factors such as adipokines, insulin, insulin resistance, and sex steroid hormones with breast cancer risk in the Indian population.

Sestrins: Darkhorse in the regulation of mitochondrial health and metabolism.

Every disease is an outcome of one or more stress signals which get convened at the interface of the mitochondria. Mitochondria and metabolism are inextricably anchored to each other and a disruption in either can result in the generation of stressors, which can lead to detrimental health consequences. Stowing everything in one frame reflects that the proteins involved in the sensing of stressors are fundamental for the initiation of various pathologies and their detailed study is necessary for proper understanding of disease mechanisms.