Publications by authors named "Deepshikha Chandel"

Article Synopsis
  • In mammals, females have two X chromosomes, but one is silenced to balance dosage between sexes, with recent research showing that the active X chromosome (Xa) is upregulated during mouse embryonic development.
  • The study explores whether reactivating the inactive X chromosome (Xi) affects Xa upregulation in various cell types, finding a correlation in some contexts like mouse embryonic epiblasts and stem cells, but not in germ cells.
  • Additionally, partial reactivation of Xi in certain cells like mouse extra-embryonic endoderm stem cells and human B cells doesn't lead to loss of Xa upregulation, leading to a new mathematical model for how both X chromosomes are coordinated in transcription.
View Article and Find Full Text PDF

In mammals, transcriptional inactivation of one X chromosome in female compensates for the dosage of X-linked gene expression between the sexes. Additionally, it is believed that the upregulation of active X chromosome in male and female balances the dosage of X-linked gene expression relative to autosomal genes, as proposed by Ohno. However, the existence of X chromosome upregulation (XCU) remains controversial.

View Article and Find Full Text PDF

Recently, allele-specific single-cell RNA-seq analysis has demonstrated widespread dynamic random monoallelic expression of autosomal genes (aRME) in different cell types. However, the prevalence of dynamic aRME during pregastrulation remains unknown. Here, we show that dynamic aRME is widespread in different lineages of pregastrulation embryos.

View Article and Find Full Text PDF

Recently, a unique form of X chromosome dosage compensation has been demonstrated in human preimplantation embryos, which happens through the dampening of X-linked gene expression from both X chromosomes. Subsequently, X chromosome dampening has also been demonstrated in female human pluripotent stem cells (hPSCs) during the transition from primed to naive state. However, the existence of dampened X chromosomes in both embryos and hPSCs remains controversial.

View Article and Find Full Text PDF

Say-Meyer syndrome is a rare and clinically heterogeneous syndrome characterized by trigonocephaly, short stature, developmental delay and hypotelorism. Nine patients with this syndrome have been reported thus far although no causative gene has yet been identified. Here, we report two siblings with clinical phenotypes of Say-Meyer syndrome with moderate to severe intellectual disability and autism spectrum disorder.

View Article and Find Full Text PDF