Noninvasive Ventilation in Myasthenia Gravis.

Background: Myasthenic crisis (MC) is mainly managed by invasive ventilation (IV) which is associated with prolonged intubation and ventilation and respiratory complication.

Aim: To report the characteristics of patients who can be managed by noninvasive ventilation (NIV) and also predictors of NIV in myasthenia gravis (MG).

Patients And Methods: In a retrospective study at tertiary care hospital in India during 2013-2015, patients with MG were evaluated.

Predictors and outcome of status epilepticus in cerebral venous thrombosis.

We report the clinico-radiological characteristics of SE in the patients with cerebral venous thrombosis (CVT), and compare the relative risk of SE in determining death and disability compared with those patients with and without self-limiting seizures. Consecutive patients with magnetic resonance venography (MRV) confirmed CVT, admitted during 2006-2017, were included. Their clinical details, risk factors, and magnetic resonance imaging and MRV findings were noted.

Evaluation of optic nerve functions in subacute combined degeneration using visual evoked potential and diffusion tensor imaging-a pilot study.

Objective:: To evaluate optic nerve involvement in subacute combined degeneration (SACD) using diffusion tensor imaging (DTI) and visual evoked potential (VEP) studies, and their changes following cobalamine treatment.

Methods:: Six patients with SACD and six healthy matched controls were included. Visual acuity, field of vision, and color vision were tested.

A Study of Super Refractory Status Epilepticus from India.

Background: Super refractory status epilepticus (SRSE) is an important and recently recognized neurological emergency.

Purpose: In view of paucity of studies on SRSE, we report the frequency, etiology and outcome of SRSE.

Methods: In a hospital-based observational study during 2013 to 2016, consecutive patients with SRSE [persistence of status epilepticus (SE) for 24 h or more, or recurrence of SE on weaning of intravenous anesthetic] were included.

Comparison of lacosamide versus sodium valproate in status epilepticus: A pilot study.

Purpose: The purpose of this study was to compare the efficacy and safety of lacosamide (LCM) and sodium valproate (SVA) in lorazepam (LOR)-resistant SE.

Methods: Patients with LOR-resistant SE were randomized to intravenous LCM 400mg at the rate of 60mg/kg/min or SVA 30mg/kg at the rate of 100mg/min. The SE severity score (STESS), duration of SE and its etiology, and MRI findings were noted.

Spectrum and Predictors of Refractory Status Epilepticus in a Developing Country.

Objective: Refractory status epilepticus (RSE) can influence the outcome of status epilepticus (SE). In the present study, we report the aetiology and predictors of outcomes of RSE in a developing country.

Methods: This is a prospective hospital-based study of SE patients (continuous seizures for five minutes or more).

Status epilepticus: Refractory and super-refractory.

Status epilepticus (SE) is an important neurological emergency. It is defined as seizures lasting for 5 minutes or more or recurrent seizures without recovery of consciousness to baseline between the attacks. Refractory SE (RSE) is defined as SE persisting despite sufficient dose of benzodiazepines and at least one antiepileptic drug (AED), irrespective of time.

A randomized controlled trial of lacosamide versus sodium valproate in status epilepticus.

Objective: To compare the efficacy and safety of lacosamide (LCM) and sodium valproate (SVA) in lorazepam (LOR)-resistant status epilepticus (SE).

Methods: Patients with LOR-resistant SE were randomized to intravenous LCM 400 mg at a rate of 60 mg/kg/min or SVA 30 mg/kg at a rate of 100 mg/min. The SE severity score (STESS), duration of SE and its etiology, and magnetic resonance imaging (MRI) findings were noted.

Direct and indirect cost of myasthenia gravis: A prospective study from a tertiary care teaching hospital in India.

Myasthenia gravis (MG) requires lifelong treatment. The cost of management MG is very high in developed countries but there is no information on the cost of management of MG in the developing countries. This study reports the direct and indirect cost and predictors of cost of MG in a tertiary care teaching hospital in India.

Cost of status epilepticus in a tertiary care hospital in India.

Purpose: Status epilepticus (SE) is one of the most important neurological emergencies. The present study evaluated both direct cost of SE and predictors of cost in an Indian tertiary care teaching hospital in Lucknow India.

Methods: SE was defined as continuous seizure for ≥ 5 min or recurrent seizures without regaining consciousness.