Publications by authors named "Deepankar Rath"
Glimepiride (GLM) is one of the potential antidiabetic drugs used in clinics for a long time. It is currently used in combination with metformin along with other drugs, but has shown various complications in patients from long-term use. Thus, the hypothesis is to use a lower dose of GLM with a non-toxic class of flavonoid, naringin (NARN), for better therapy with minimal side-effects.
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- Proton pump inhibitors (PPIs) are widely prescribed for acid-related disorders, but their long-term effects on bone health are becoming a concern.
- A review of 27 studies found a significant increase in fracture risks, particularly in the hip, spine, and wrist, as well as changes in Bone Mineral Density (BMD) among PPI users, despite uncertainty about the clinical impact.
- The evidence also suggested risks of hypomagnesemia and dental implant failures in PPI users, but the overall confidence in these findings was rated as very low to low, indicating a need for more rigorous studies.
Objective: Evaluation of the synergistic effect of Naringin and Glimepiride in streptozotocin (STZ)-induced diabetic rats.
Methods: Wistar rats were chosen and divided into five groups (n=6). STZ was used for the induction of diabetes.