Clinical phenotype of severe and moderate haemophilia: Who should receive prophylaxis and what is the target trough level?

Introduction: One of the most often stated tenets of haemophilia care is that prophylaxis converts a person from a severe to a moderate phenotype. In this review, we argue that this is not an accurate assumption and that people on prophylaxis predominantly have factor VIII/IX levels in the mild range.

Moderate Haemophilia And Prophylaxis: People with moderate haemophilia, who are treating with on-demand regimens, experience joint bleeds and often develop significant arthropathy.