Biological evaluation of trans-2,3-dihydrofuro[3,2-c]coumarins as potential cathepsin inhibitors and anticancer agents.

Novel trans-2,3-dihydrofuro[3,2-c]coumarins were synthesized and assessed for their inhibition potential against cysteine proteases: cathepsin B, H and L which are the possible targets for anticancer activity. In general, the coumarin derivatives were found to be exceptional inhibitors against this class of enzymes. On the basis of molecular modeling data and structure-activity relationships, their inhibition patterns are also discussed.

Naphthoquinone fused diazepines targeting hyperamylasemia: potential therapeutic agents for diabetes and cancer.

Elevated levels of amylase in the blood, known as hyperamylasemia, have been correlated with diabetes and cancer. To investigate the impact of hyperamylasemia on cellular proliferation, it is imperative to design dual inhibitors targeting both α-amylase activity and cancer progression. Naphthoquinone fused diazepines have been synthesized using multicomponent reaction with high Eco-score of 87 and evaluated for bio efficacy using antioxidant and α-amylase inhibition assay.

Correction: Electro-organic synthesis: an environmentally benign alternative for heterocycle synthesis.

Correction for 'Electro-organic synthesis: an environmentally benign alternative for heterocycle synthesis' by Suman Devi, , , 2022, , 5163-5229.

Electro-organic synthesis: an environmentally benign alternative for heterocycle synthesis.

Heterocyclic compounds are considered to be one of the most established structural classes due to their extensive application in agrochemicals, pharmaceuticals and organic materials. Over the past few years, the development of heterocyclic compounds has gone through a considerable renaissance from conventional traditional methodologies to non-conventional electro-organic synthesis. Replacing metal catalysts, strong oxidants and multi-step methodologies with metal and strong oxidant-free single-step protocols has revolutionized the field of sustainable organic synthesis.

Synthesis and antimicrobial evaluation of new 1,4-dihydro-4-pyrazolylpyridines and 4-pyrazolylpyridines.

Background: Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates (1,4-DHP) have now been recognized as vital drugs. Some of these derivatives such as amlodipine, felodipine, isradipine, etc. have been commercialized.