Antioxidants and Mechanistic Insights for Managing Dry Age-Related Macular Degeneration.

Age-related macular degeneration (AMD) severely affects central vision due to progressive macular degeneration and its staggering prevalence is rising globally, especially in the elderly population above 55 years. Increased oxidative stress with aging is considered an important contributor to AMD pathogenesis despite multifaceted risk factors including genetic predisposition and environmental agents. Wet AMD can be managed with routine intra-vitreal injection of angiogenesis inhibitors, but no satisfactory medicine has been approved for the successful management of the dry form.

Tikaram and Chandrakala Dhananjaya: A collaborative couple in mathematics from Nepal.

Within the history of mathematics and mathematics education in Nepal, Tikaram and Chandrakala Dhananjaya are relatively well-known figures for their two books Śiśubodha Taraṅgiṇī and Līlāvatī. This is despite there being almost no archival or manuscript materials offering a window into their lives: we have no letters, notebooks, diaries, or school records. Rather than focusing on either individual in isolation, in this article we present an argument for considering the Dhananjayas as an analytically indivisible collaborative couple in mathematics.

Prevalence, antimicrobial susceptibility pattern and multidrug resistance of methicillin-resistant isolated from clinical samples at a tertiary care teaching hospital: an observational, cross-sectional study from the Himalayan country, Nepal.

Objective: We sought to determine the prevalence and antimicrobial susceptibility pattern of methicillin-resistant (MRSA) isolated from the clinical samples at a tertiary care hospital in Nepal.

Methods: Cross-sectional, observational study design.

Study Setting: The study was carried out at a tertiary care facility, the largest public hospital, Tribhuvan University Teaching Hospital (TUTH), Nepal.