Anti-inflammatory Effects of Siponimod in a Mouse Model of Excitotoxicity-Induced Retinal Injury.

Glaucoma is a leading cause of permanent blindness worldwide and is characterized by neurodegeneration linked to progressive retinal ganglion cell (RGC) death, axonal damage, and neuroinflammation. Glutamate excitotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors plays a crucial role in glaucomatous RGC loss. Sphingosine 1-phosphate receptors (S1PRs) are important mediators of neurodegeneration and neuroinflammation in the brain and the retina.

Efficacy and Safety of iStent Inject Implantation in Manual and Femtosecond Laser-assisted Cataract Surgery before Lens Extraction.

Aim: To describe the efficacy and safety of iStent implantation prior to phacoemulsification in manual as well as femtosecond laser-assisted cataract surgery (FLACS), and highlight this approach as a reasonable, if not necessary, step to advance one's ability and confidence in the use of microinvasive glaucoma surgery (MIGS) technology in phakic patients.

Methods: A retrospective consecutive case series of patients with open angle glaucoma or ocular hypertension who underwent iStent inject implantation followed by cataract surgery (manual or FLACS). All cases underwent postoperative video review and were assessed and classified for intraoperative lens injury and hyphaema.

PARACENTRAL ACUTE MIDDLE MACULOPATHY IN SUSAC SYNDROME.

Purpose: To present the first reported case of paracentral acute middle maculopathy in association with Susac syndrome.

Method: Case report.

Results: A young female patient presented with unilateral sudden loss of vision of her right eye to count fingers.

Corneal Collagen Crosslinking for Post-LASIK Ectasia: An Australian Study.

Purpose: Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-term efficacy of CXL for post-LASIK ectasia in an Australian setting.

Relationship of Structural Characteristics to Biomechanical Profile in Normal, Keratoconic, and Crosslinked Eyes.

Purpose: To evaluate the correlation of corneal biomechanical parameters with structural characteristics in normal, keratoconic, and collagen crosslinked eyes.

Methods: A prospective observational study that included 50 normal, 100 keratoconic, and 25 crosslinked eyes. All eyes were imaged using a Scheimpflug camera and an ocular response analyzer.

The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis.

Human SCO1 fulfills essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper (Cu) homeostasis, yet it remains unclear why pathogenic mutations in this gene cause such clinically heterogeneous forms of disease. Here, we establish a Sco1 mouse model of human disease and show that ablation of Sco1 expression in the liver is lethal owing to severe COX and Cu deficiencies. We further demonstrate that the Cu deficiency is explained by a functional connection between SCO1 and CTR1, the high-affinity transporter that imports Cu into the cell.

Comparative analysis of corneal measurements obtained from a Scheimpflug camera and an integrated Placido-optical coherence tomography device in normal and keratoconic eyes.

Purpose: To assess the agreement between a Scheimpflug camera (Pentacam) and a combined Placido-optical coherence tomography device (Visante OMNI) in measuring corneal curvature, thickness and elevation values in normal and keratoconic eyes.

Methods: Corneal measurements of 110 normal eyes (one eye per subject) and 70 keratoconic eyes were obtained from both devices and compared. Agreement was determined using the Bland-Altman analysis 95% limits of agreement (LoA).

Outcome of corneal collagen crosslinking for progressive keratoconus in paediatric patients.

Purpose: To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients.

Methods: This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370 nm, 3 mW/cm2, 30 min).

Results: The mean patient age was 14.

Bilateral femtosecond laser-enabled intrastromal astigmatic keratotomy to correct high post-penetrating keratoplasty astigmatism.

A 35-year-old man presented with bilateral high astigmatism following penetrating keratoplasties performed for advanced keratoconus. Femtosecond laser-enabled intrastromal astigmatic keratotomy was performed, resulting in a significant reduction in corneal astigmatism. At 4 months, the corneal astigmatism continued to decrease.

Relationship of change in central corneal thickness to visual field progression in eyes with glaucoma.

Background: To assess the relationship between baseline central corneal thickness (CCT) and/or ongoing CCT change over time with subsequent visual field progression.

Methods: One hundred sixty three eyes of 163 patients with medically treated glaucoma were followed up for 6.8 ± 1.

Prospective longitudinal study of corneal collagen cross-linking in progressive keratoconus.

Background: Collagen cross-linking has been reported to be effective in treating progressive keratoconus, and this study aims to evaluate the long-term efficacy of this procedure.

Design: Prospective longitudinal interventional study of patients with progressive keratoconus who underwent cross-linking in a tertiary referral hospital.

Participants: Thirty-five patients (51 eyes) who underwent cross-linking with a mean follow-up of 14.

Longitudinal effect of topical antiglaucoma medications on central corneal thickness.

Background: To determine the change in central corneal thickness over time and whether the use of long-term topical antiglaucoma medications influences central corneal thickness.

Design: Case control study with retrospective and prospective data collection.

Participants: One hundred eighty-seven eyes of 187 glaucoma patients (mean follow up 6.

The effect of stimulus expectancy on dishabituation of auditory evoked potentials.

Objectives: Having foreknowledge of the type and timing of sensory stimulation modulates the electrophysiological response and can result in short-term habituation. Here we explore if dishabituation is similarly affected.

Methods: Seventeen healthy subjects were tested with five different auditory stimuli paradigms to see if knowledge of the stimulus train length and/or deviant stimulus affects the amount of dishabituation of auditory evoked potentials.

Wavefront aberrations in eyes with decentered ablations.

Purpose: To compare the refractive and functional outcomes and wavefront profiles in eyes with decentered ablations and eyes with well-centered ablations.

Setting: Medical Research Foundation, Chennai, Tamil Nadu, India.

Methods: This retrospective analysis comprised eyes with topographically diagnosed decentered ablations after laser in situ keratomileusis (LASIK).

Wavefront-guided versus wavefront-optimized laser in situ keratomileusis: contralateral comparative study.

Purpose: To compare the outcomes of wavefront-guided and wavefront-optimized treatment in fellow eyes of patients having laser in situ keratomileusis (LASIK) for myopia.

Setting: Medical and Vision Research Foundation, Tamil Nadu, India.

Methods: This prospective comparative study comprised 27 patients who had wavefront-guided LASIK in 1 eye and wavefront-optimized LASIK in the fellow eye.

Hyperplastic persistent pupillary membranes with congenital corneal anomalies.

We report a case of a 14-year-old girl who presented with impaired vision in the left eye since birth. Examination showed extensive bilateral persistent pupillary membranes associated with microcornea, cornea plana, and central localized posterior keratoconus in both eyes. The uncorrected visual acuity was 0.

Novel SLC4A11 mutations in patients with recessive congenital hereditary endothelial dystrophy (CHED2). Mutation in brief #958. Online.

Autosomal recessive congenital hereditary endothelial dystrophy (CHED2) is a severe and rare corneal disorder that presents at birth or shortly thereafter, characterized by corneal opacification and nystagmus. Recently the gene for CHED2 was identified and seven different mutations in the SLC4A11 gene were reported. Here, we report seven novel mutations and two previously identified mutations in families from India and the United Kingdom with recessive CHED.