Functionalized Nanomaterials In Pancreatic Cancer Theranostics And Molecular Imaging.

Pancreatic cancer (PC) is one of the most fatal malignancies in the world. This lethality persists due to lack of effective and efficient treatment strategies. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive epithelial malignancy which has a high incidence rate and contributes to overall cancer fatalities.

Hybridoma generation by in vitro immunization of murine splenocytes with cytosolic proteins of Chinese hamster ovary (CHO) mitotic cells.

Despite the potential uses of polyclonal antisera, monoclonal antibodies (MAbs) are preferred for target-specific applications. In vitro immunizations toward the development of hybridomas have become more advantageous in situations of limited antigen availability, small molecular size, and the duration required for the production of MAbs. Cells in the mitotic stage are distinct in their protein profiles compared to cells in the other stages of the cell cycle, and studying these proteins can give various insights into the mechanisms of cell cycles and the interventional scenario, such as mitotic inhibition.