Unlocking an additive-free and catalyst-free dual approach for reduction of amides to amines.

We report a two-fold strategy to convert amides to amines in the presence of dimethylamine-borane as the hydrogen source. In the absence of any additive, the formation of the amines resulted from reduction of the amides. On the other hand, in the presence of TMEDA and dimethylamine-borane, tertiary amines were obtained from primary amides in a one-pot fashion.

Insight into the MOBu (M=Na, K)-Mediated Dehydrogenation of Dimethylamine-Borane and Transfer Hydrogenation of Nitriles to Primary Amines.

Selective synthesis of primary amines from nitriles is challenging in synthetic chemistry due to the possible en-route generation of various amines and imines. Herein, we report a practical and operationally simple MOBu-mediated (M=Na, K) transfer hydrogenation of nitriles to the corresponding primary amines with a relatively unexplored sacrificial hydrogen source (dimethylamine borane). The strategy encompasses a broad substrate scope under transition metal-free conditions and does not require any solvent.

Transfer semi-hydrogenation of terminal alkynes with a well-defined iron complex.

The synthesis and characterization of a bis-iron(II) complex was accomplished upon treatment of a phosphine free NNN-pincer ligand (L) with FeCl·4HO under ambient conditions. The deep greenish colored iron(II) complex (Fe-1) was characterized by a single-crystal X-ray diffraction study along with IR spectroscopy, UV-Vis spectroscopy, mass spectrometry, and elemental analysis. The Fe-1 complex was tested for the transfer semi-hydrogenation of terminal alkynes to the corresponding alkenes through the dehydrogenation of dimethyl amine-borane.

Easy Access to Tertiary Amines from Carbonyl Compounds with Substituted Amine-Boranes: A Substrate, Catalyst, and Additive-Free Approach Under Mild Conditions.

Tertiary amines are ubiquitous and play an essential role in organocatalysis, pharmaceuticals, and fine chemicals. Amongst various synthetic procedures known for their synthesis, the reductive amination of carbonyl compounds has been found to be a proficient method. Over the past few decades, different synthetic strategies for reductive amination have been developed.

Cyclotrimetaphosphate-assisted ruthenium catalyst for the hydration of nitriles and oxidation of primary amines to amides under aerobic conditions in water.

Amide bonds are ubiquitous and regarded as an essential constituent of many biologically active drug molecules and fine chemicals. We report a practical and operationally simple ruthenium-based catalytic system for the hydration of nitriles and aerobic oxidation of primary amines to the corresponding amides. Both reactions proceed without any external oxidant in water under aerobic conditions and exhibit a broad substrate scope.

Transamidation of aromatic amines with formamides using cyclic dihydrogen tetrametaphosphate.

Amide fragments are found to be one of the key constituents in a wide range of natural products and pharmacologically active compounds. Herein, we report a simple and efficient procedure for transamidation with a cyclic dihydrogen tetrametaphosphate. The protocol is simple, does not require any additives, and encompasses a broad substrate scope.