Publications by authors named "Deeman Mirza"
Article Synopsis
- Serine is encoded by two distinct codons (UCN and AGY), and switching between them involves intermediate residues like threonine or cysteine and cannot occur through single nucleotide changes.
- Hepatitis C virus (HCV) infects a significant portion of the population and its surface glycoproteins (E1 and E2) are crucial for infection and immune response, showing evidence of historical codon-switching events at conserved serine residues.
- Analysis reveals that the presence of intermediate phenotypes is limited due to their negative impact on HCV functionality and their increased vulnerability to immune targeting, leading to natural selection that restricts their prevalence in global HCV lineages.
