Disease-specific Mortality of Differentiated Thyroid Cancer With Distant Metastases.

Overview: Distant metastases (DM) are the major cause of death in patients with differentiated thyroid cancer (DTC). This study aimed to investigate the predictors of DM-associated mortality.

Patients And Methods: We identified 154 thyroid cancer (TC) patients with DM from our institution's tumor registry.

Assessment of fatigue severity and neurocognitive functions in the real setting of Ramadan in patients with type 2 diabetes mellitus.

Objectives: Type 2 diabetes mellitus (T2DM) is linked with a risk of dementia and decline in neurocognitive function. The current observational case-control study was conducted to evaluate the effect of fasting during Ramadan on cognitive functions and fatigue severity in T2DM patients using the Cambridge Neuropsychological Test Automated Battery (CANTAB).

Methods: This research was conducted at King Saud University Medical city, on 82 subjects including 43 control and 39 T2DM patients of both genders.

Design, synthesis, molecular modeling and biological evaluation of novel diaryl heterocyclic analogs as potential selective cyclooxygenase-2 (COX-2) inhibitors.

New series of 3,4-diaryl-2-thioxoimidazolidin-4-ones and 3-alkylthio-4,5-diaryl-4-1,2,4-triazoles were designed, synthesized and evaluated for their activity as anti-inflammatory agents. Compounds , , and are highly selective inhibitors of COX-2 enzyme at a concentration of 100 mM relative to celecoxib, the standard reference. (±)-3-(4-Phenoxy-phenyl)-5-phenyl-2-thioxoimidazolidin-4-ones exhibited the most active anti-inflammatory agent.