Endogenous endophthalmitis: New insights from a 12-year cohort study.

Objectives: To describe the clinical and microbiological characteristics of patients with endogenous endophthalmitis (EE), determine factors associated with outcome and propose a management plan for EE.

Methods: Retrospective case series in two tertiary referral centers from 2010 to 2022.

Results: Sixty-four eyes of 53 patients were included.

Hodgkin Lymphoma Associated Retinopathy: Report of a Case.

Purpose: To report a case of Hodgkin lymphoma (HL) associated retinopathy.

Method: Single-case, retrospective review of ophthalmological and systemic manifestations.

Results: A bilateral panuveitis in a 17-year-old Caucasian woman led to the diagnosis of HL.

Estimating the causal effect of an exposure on change from baseline using directed acyclic graphs and path analysis.

When estimating the causal effect of an exposure of interest on change in an outcome from baseline, the choice between a linear regression of change adjusted or unadjusted for the baseline outcome level is regularly debated. This choice mainly depends on the design of the study and the regression-to-the-mean phenomena. Moreover, it might be necessary to consider additional variables in the models (such as factors influencing both the baseline value of the outcome and change from baseline).

Childhood adversity as a risk for cancer: findings from the 1958 British birth cohort study.

Background: To analyse whether Adverse Childhood Experiences (ACE) are associated with an increased risk of cancer.

Methods: The National child development study (NCDS) is a prospective birth cohort study with data collected over 50 years. The NCDS included all live births during one week in 1958 (n=18558) in Great Britain.

Adverse childhood experiences and premature all-cause mortality.

Events causing stress responses during sensitive periods of rapid neurological development in childhood may be early determinants of all-cause premature mortality. Using a British birth cohort study of individuals born in 1958, the relationship between adverse childhood experiences (ACE) and mortality≤50 year was examined for men (n=7,816) and women (n=7,405) separately. ACE were measured using prospectively collected reports from parents and the school: no adversities (70%); one adversity (22%), two or more adversities (8%).

Estimating controlled direct effects in the presence of intermediate confounding of the mediator-outcome relationship: Comparison of five different methods.

In mediation analysis between an exposure X and an outcome Y, estimation of the direct effect of X on Y by usual regression after adjustment for the mediator M may be biased if Z is a confounder between M and Y, and is also affected by X Alternative methods have been described to avoid such a bias: inverse probability of treatment weighting with and without weight truncation, the sequential g-estimator and g-computation. Our aim was to compare the usual linear regression adjusted for M to these methods when estimating the controlled direct effect between X and Y in the causal structure and to explore the size of the potential bias. Estimations were computed in several simulated data sets as well as real data.

Microdialysis study of striatal dopaminergic dysfunctions induced by 3 MPa of nitrogen- and helium-oxygen breathing mixtures in freely moving rats.

Previous studies have demonstrated opposite effects of high-pressure helium and nitrogen on extracellular dopamine (DA) levels, which may reflect disturbances on the synthesis, release or metabolic mechanisms. Intrastriatal microdialysis was used to measure the precursor (tyrosine), DA and its metabolites (DOPAC, HVA) levels under nitrogen- or helium- at pressure up to 3 MPa. Under 3 MPa of helium-oxygen breathing mixtures, the extracellular concentration of tyrosine is decreased while the extracellular concentration of DA is increased.