Influence of salmon calcitonin on the analgesic effect of selective kappa-opioid agonist in mice.

In the present study the relationship between calcitonin and kappa-opioid system was analysed. The possibility that salmon calcitonin (S-CT) exerts analgesic activity in mice as well as the influence of salmon calcitonin on the analgesic effect of kappa-opioid agonist, U-50, 488H were examined. The writhing test in mice was used as analgesic test.

Changes in rabbits' behaviour under the influence of corticotropin derivative analogue 4-10 in spontaneous conditions.

The influence and the role of corticotrophin analogue 4-10 on the rabbits' behaviour in spontaneous conditions was analysed. The data analysis indicated that analogue 4-10 with modified aminoacid sequence in 8, 9, 10 positions significantly influenced the behavioural changes in the general model of behaviour. The 4-10 corticotrophin derivative caused the suppression of aggression, considerably reduced the tension and orientation-cognition reactions, however, it prolonged comfort and grooming significantly.