Pharmacodynamic Effects of Pioglitazone on High Molecular Weight Adiponectin Concentrations and Insulin Response After Oral Sugar in Equids.

Chronic insulin dysregulation is challenging to manage with pharmaceuticals in horses. Pioglitazone improves insulin sensitivity in humans, and the pharmacokinetics of pioglitazone have been evaluated in horses. The objectives of this study were to assess the pharmacodynamic effects of oral pioglitazone on morphometric parameters, hepatic enzyme activity and function, adipokines, and enteroinsular response to oral sugar.

Effect of exercise and environmental terrain on development of the digital cushion and bony structures of the bovine foot.

Objective: To determine whether exercise on alternative terrain affects the development of the digital cushion and bony structures of the bovine foot.

Animals: 20 weaned bull calves.

Procedures: Two-month-old calves were randomly allocated to an exercise or control group.

Evaluation of high-molecular weight adiponectin in horses.

Objective: To characterize adiponectin protein complexes in lean and obese horses.

Animals: 26 lean horses and 18 obese horses. Procedures-Body condition score (BCS) and serum insulin activity were measured for each horse.