A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients.

Objective: Recent molecular, preclinical, and preliminary clinical studies suggest that the therapeutic effects of mood stabilizers may be mediated by modulating expression of potent neurotrophic and neuroprotective factors having the potential to reverse impairments of cellular resilience, reductions in brain volume, and cell death or atrophy. Our main goal was to investigate the potential clinical significance of these findings in relation to bipolar disorder.

Method: The longitudinal effect of lithium on brain gray matter volume was investigated in well-characterized (DSM-IV criteria) bipolar depressed subjects (N = 28) at baseline (medication-free) and after lithium administration (4 weeks).

Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative.

We conducted genomewide linkage analyses on 1,152 individuals from 250 families segregating for bipolar disorder and related affective illnesses. These pedigrees were ascertained at 10 sites in the United States, through a proband with bipolar I affective disorder and a sibling with bipolar I or schizoaffective disorder, bipolar type. Uniform methods of ascertainment and assessment were used at all sites.

Significant difference in beat-to-beat QT interval variability among different leads.

QT interval on the surface electrocardiogram (ECG) reflects the time for repolarization of myocardium, and QTc prolongation is strongly associated with sudden cardiac death. Findings of studies that have examined the dispersion of QT interval in 12-lead ECGs strongly suggest that an increased QT dispersion between different leads is associated with an increased risk of cardiac mortality. Recent studies using novel techniques on beat-to-beat QT interval variability have also shown that the interval is both influenced by the autonomic nervous system and a predictor of sudden cardiac death.

Mood disorders: treatment-induced changes in brain neurochemistry and structure.

Continuing advances in neuroimaging technology as well as postmortem examinations have enabled researchers to begin to accumulate substantial evidence suggesting that chronic mood disorders may be associated with actual structural and neurochemical changes within the brain. There is emerging evidence to suggest that various treatment modalities may also induce measurable changes within the brain detectable with specialized neuroimaging techniques, which may be responsible for their clinical therapeutic effects. One such specialized neuroimaging technique, magnetic resonance spectroscopy (MRS), is briefly reviewed.

Heart rate time series: decreased chaos after intravenous lactate and increased non-linearity after isoproterenol in normal subjects.

In this study, we reanalyzed our previous heart rate time series data on the effects of intravenous sodium lactate (n=9) and intravenous isoproterenol (n=11) using non-linear techniques. Our prior findings of significantly higher baseline non-linear scores (NL: S(netGS)) and significantly lower largest Lyapunov exponents in supine posture in patients with panic disorder compared to control subjects prompted this study. We obtained the largest Lyapunov exponent (LLE), and a measure of non-linearity (NL: S(netGS)) of heart rate time series.