Publications by authors named "Debra Chapman"
The inhibitory activity of myelin-associated glycoprotein (MAG) on neurons is thought to contribute to the lack of regenerative capacity of the CNS after injury. The interaction of MAG and its neuronal receptors mediates bidirectional signaling between neurons and oligodendrocytes. The novel finding that an anti-MAG monoclonal antibody not only possesses the ability to neutralise the inhibitory effect of MAG on neurons but also directly protects oligodendrocytes from glutamate-mediated oxidative stress-induced cell death is reported here.
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- Myelin-associated glycoprotein (MAG) interacts with neuronal receptors to inhibit neurite growth while maintaining myelin integrity through a bidirectional signaling system.
- MAG is found in specialized lipid-raft regions of cell membranes, which is influenced by cholesterol and glycosylation processes, allowing for effective communication between cells.
- The presence of MAG and its receptors in these lipid rafts encourages strong interactions necessary for signaling, enhancing the transmission of information between myelin and neurons.