Publications by authors named "Debra A Tanguay"
Am J Pharmacogenomics
September 2003
Article Synopsis
- G-proteins are crucial drug targets, with genetic differences in individuals affecting their response to related medications.
- Research analyzed the genetic variations in 64 GPCR genes among 82 people from diverse ethnic backgrounds, identifying 675 single-nucleotide variations.
- Key findings revealed a high prevalence of non-synonymous SNPs in GPCR genes, especially in transmembrane domains, suggesting that genetic variability could significantly impact drug development for these receptors.
