Publications by authors named "Debordeaux F"
In primary immune thrombocytopenia (ITP), predictors of disease evolution and treatment response are needed. Data based on the site of platelet destruction are scarce. We performed a retrospective single-centre study of adult patients with primary ITP undergoing at least one Indium-111 platelet scintigraphy (IPS) between 2009 and 2018.
View Article and Find Full Text PDFBackground: The regenerative capacities of the liver and improvements in surgical techniques have expanded the possibilities of resectability. Liver resection is often the only curative treatment for primary and secondary malignancies, despite the risk of post-hepatectomy liver failure (PHLF). This serious complication (with a 50% mortality rate) can be avoided by better assessment of liver volume and function of the future liver remnant (FLR).
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- - Hepatocellular carcinoma (HCC) is a major global health issue, being one of the most common cancers and a leading cause of cancer deaths, with intra-arterial therapies like TACE and SIRT being key treatment options for non-resectable cases.
- - TACE is typically used for patients with stage B HCC, while SIRT has shown promising results in patients previously treated with TACE, despite not having an official role in treatment guidelines.
- - A study involving 23 patients indicated that SIRT post-TACE resulted in a 73.8% objective response rate, with 56.5% achieving complete response, highlighting SIRT's potential effectiveness despite the complications associated with TACE.
Background: Thrombocytopenia occurs in 60% of patients with myelodysplastic syndromes (MDS), increasing the risk of life-threatening haemorrhage in this population of mainly old patients with comorbidities. However, data are scare regarding immune thrombocytopenia (ITP) secondary to MDS.
Aim: We analyzed the utility of indium-111 platelet scintigraphy (IPS) to better characterize the mechanisms of thrombocytopenia in 21 adult patients with MDS.
Article Synopsis
- The study investigates the calculation of yttrium-90 microspheres activity essential for selective internal radiotherapy (SIRT).
- Using dosimetry software, researchers analyzed the absorbed doses to both tumors and healthy liver tissue before and after treatment phases.
- Results indicated significant correlations in dose distribution and suggested that optimizing microsphere dosages could enhance treatment effectiveness for some patients while reducing it for others.
Purpose: Selective internal radiotherapy with 90Y microspheres is widely used for the treatment of patients with liver cancer. A dosimetric analysis using the dosimetry software Simplicit90y (Boston Scientific, Natick, MA) was conducted to define doses to the tumor and healthy liver, and to determine a threshold tumor dose that could predict progression-free survival.
Methods: Patients experiencing hepatocellular carcinoma and treated with 90Y-labeled resin microspheres were included in a retrospective study.
Background: Transarterial radioembolization (TARE) is widely used for the treatment of hepatocellular carcinoma (HCC), but early treatment response can be very difficult to assess. The aim was to evaluate 18F-fluorocholine PET/computed tomography (CT) to assess the treatment response in patients with intermediate or locally advanced HCC.
Methods: Between March 2019 and July 2020, nine HCC patients treated with TARE, who underwent PET/CT at baseline and 1 month after treatment, were enrolled.
Purpose: To compare the reliability and accuracy of the pre-treatment dosimetry predictions using cone-beam computed tomography (CBCT) versus Tc-labeled macroaggregated albumin (MAA) SPECT/CT for perfused volume segmentation in patients with hepatocellular carcinoma treated by selective internal radiation therapy (SIRT) using Y-glass microspheres.
Materials And Methods: Fifteen patients (8 men, 7 women) with a mean age of 68.3±10.
Article Synopsis
- The study compares the effectiveness of white blood cell (WBC) scans and F-FDG PET/CT in diagnosing prosthetic vascular graft infections (PVGIs), highlighting that early diagnosis is crucial for improving treatment outcomes.
- A retrospective analysis of 39 patients, conducted at Bordeaux University Hospital, showed that 15 had PVGI, with the WBC scan demonstrating significantly greater accuracy than F-FDG PET/CT based on ROC curve analysis.
- The findings suggest that WBC scans are more reliable for PVGI diagnosis, as indicated by higher diagnostic value and better interobserver agreement, making it a preferred choice in clinical settings.
Background: The usage of left-ventricular-assist device (LVAD) is increasing in patients presenting with advanced heart failure. However, device-related infections are a challenge to recognize and to treat, with an important morbidity and mortality rate. The role of nuclear medicine imaging remains not well established for LVAD infections.
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- - Non-invasive integrin expression investigation is gaining attention in nuclear medicine due to its role in various diseases like tumors, cardiovascular issues, and immune problems.
- - Key targets for monitoring angiogenesis include VEGF, matrix metalloproteases, and integrins, which can help in early diagnosis and treatment decisions.
- - The review emphasizes the use of αβ integrin as a biomarker for cancer, exploring imaging techniques such as SPECT and PET, and advancements in radiolabeling and therapy approaches.
The human Matrix MetalloProtease-9 (hMMP-9) is overexpressed in tumors where it promotes the release of cancer cells thus contributing to tumor metastasis. We raised aptamers against hMMP-9, which constitutes a validated marker of malignant tumors, in order to design probes for imaging tumors in human beings. A chemically modified RNA aptamer (F3B), fully resistant to nucleases was previously described.
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