Publications by authors named "Deborah Reynaud"
Methods Mol Biol
November 2023
Article Synopsis
- Gestational trophoblastic diseases (GTD) include rare tumors related to pregnancy, with gestational choriocarcinoma (CC) being a highly aggressive type that can lead to high mortality if not treated quickly.
- CC has a higher incidence in molar pregnancies and poses greater risks in developing countries, with rates as high as 20 cases per 1,000 pregnancies.
- A new animal model for CC was created by injecting specific cancer cells into the placenta of pregnant mice, allowing researchers to mimic cancer development and metastasis, which highlights the role of placental blood vessels in spreading the tumor.
Article Synopsis
- Gestational choriocarcinoma (GC) is a serious tumor connected to hydatidiform moles, with NLRP7 being a key gene linked to its development and immune response.
- *Research shows that NLRP7 can operate through different pathways, significantly influencing cancer cell survival and aggressive traits in tumor cells compared to non-tumor cells.
- *Finding that NLRP7 plays a crucial role in GC growth suggests it could be a valuable target for new treatment strategies for resistant patients.
Biomedicines
January 2022
Article Synopsis
- Gestational choriocarcinoma (CC) is a serious type of cancer linked to abnormal pregnancies, often leading to metastasis and maternal mortality.
- Recent research indicates a connection between recurrent hydatidiform moles and mutations in the NLRP7 gene, which is involved in immune responses.
- NLRP7 is found to be overexpressed in CC cells, promoting immune tolerance and affecting cell behavior, which may contribute to both normal placentation and the aggressiveness of choriocarcinoma.
Cancers (Basel)
June 2021
Article Synopsis
- * Researchers employed clinical analysis of placentas and sera, in vitro studies on tumor growth, and in vivo mouse models to study NLRP7's impact on CC.
- * Findings revealed that NLRP7 promotes tumor cell proliferation and organization, while its absence in pregnant mice led to stronger maternal immune responses and reduced tumor growth and metastasis, highlighting its role in creating an immunosuppressive environment that aids CC progression.
Article Synopsis
- - EG-VEGF, a member of the prokineticin family, plays a key role in human placental development and is linked to pregnancy issues like preeclampsia and fetal growth restriction.
- - Research shows that targeting its receptors (PROKR1 and PROKR2) with antagonists (PC7 and PKRA) can reverse unhealthy effects, suggesting a potential therapeutic approach for pregnancy complications.
- - A study demonstrated that using these antagonists improves trophoblast cell functions and supports better fetal growth, indicating their potential as safe treatments to enhance pregnancy outcomes.
J Mol Med (Berl)
January 2020
Article Synopsis
- Preeclampsia (PE) is a serious pregnancy condition that occurs due to improper trophoblast cell invasion affecting blood circulation between the mother and fetus.
- CK2, an enzyme involved in cellular processes, was found to be more active during early pregnancy and its inhibition negatively impacted trophoblast cell functions essential for healthy development.
- The study observed that CK2 activity increases in placentas from PE patients and in PE mouse models, suggesting its role in supporting feto-maternal circulation, potentially indicating a compensatory response to the challenges in PE.
Article Synopsis
- - PROK1 levels in individual follicular fluid (FF) have been identified as a promising biomarker to predict the competence of oocytes in IVF, with a strong correlation to follicular size.
- - A study conducted at the University Hospital of Grenoble with 69 infertile couples confirmed that higher PROK1 concentrations in FF are indicative of better embryo development potential, independent of other embryo growth indicators.
- - The research suggests that hormones like Follicle Stimulating Hormone (FSH) and hCG can enhance PROK1 secretion, potentially affecting oocyte quality through biological pathways linked to cAMP.
Methods Mol Biol
July 2018
Article Synopsis
- Researchers created new animal models to study pregnancy-induced hypertension (PIH), which includes conditions like gestational hypertension and preeclampsia.
- They found evidence that a factor called EG-VEGF may play a role in the development of PIH.
- A specific protocol showed that keeping EG-VEGF levels high in pregnant mice for over 11 days led to symptoms resembling preeclampsia.
