Publications by authors named "Deborah Paolucci"
PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells.
Am J Physiol Renal Physiol
June 2023
Article Synopsis
- PCK1 (phosphoenolpyruvate carboxykinase 1) is a key enzyme in kidney cells that helps convert oxaloacetate to phosphoenolpyruvate and plays a role in maintaining metabolic processes such as gluconeogenesis and ammoniagenesis.
- Deleting PCK1 in kidney-specific knockout mice led to metabolic issues including hyperchloremic metabolic acidosis and altered metabolism, causing kidney injury and decreased ATP production.
- Enhancing PCK1 expression during chronic kidney disease improved renal function, highlighting its importance for acid-base balance, energy production, and overall tubular health.