Impact of Western Diet on Enterohemorrhagic Colonization in the Human Mucosal Artificial Colon as Mediated by Gut Microbiota.

Enterohemorrhagic (EHEC) is a major food-borne pathogen that causes human disease ranging from diarrhea to life-threatening complications. Accumulating evidence demonstrates that the Western diet enhances the susceptibility to enteric infection in mice, but the effect of diet on EHEC colonization and the role of human gut microbiota remains unknown. Our research aimed to investigate the effects of a Standard versus a Western diet on EHEC colonization in the human Mucosal ARtificial COLon (M-ARCOL) and the associated changes in the gut microbiota composition and activities.