Bioavailability of a novel midazolam gel after intranasal administration in dogs.

Objective: To compare the pharmacokinetics of a novel bioadhesive gel formulation of midazolam after intranasal (IN) administration with that of midazolam solution after IN, IV, and rectal administration to dogs.

Animals: 10 (5 males and 5 females) healthy adult Beagles.

Procedures: Dogs were assigned to 4 treatment groups for a crossover study design.