Publications by authors named "Deborah A van den Brink"
Objective: To determine which risk prediction model best predicts clinical deterioration in children at different stages of hospital admission in low- and middle-income countries.
Methods: For this systematic review, Embase and MEDLINE databases were searched, and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. The key search terms were "development or validation study with risk-prediction model" AND "deterioration or mortality" AND "age 0-18 years" AND "hospital-setting: emergency department (ED), pediatric ward (PW), or pediatric intensive care unit (PICU)" AND "low- and middle-income countries.
Children with severe acute malnutrition (SAM) display immature, altered gut microbiota and have a high mortality risk. Faecal volatile organic compounds (VOCs) reflect the microbiota composition and may provide insight into metabolic dysfunction that occurs in SAM. Here we determine whether analysis of faecal VOCs could identify children with SAM with increased risk of mortality.
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- * In a randomized double-blind study involving 843 hospitalized children in Kenya and Malawi, the median time to clinical stabilization was similar between mF75 and F75 groups, and there were no significant differences in in-hospital mortality or diarrheal episodes.
- * The trial did not find a significant advantage of the modified formula over the standard one for reducing complications or improving recovery time, highlighting the complexity of treating severe malnutrition in children. *
The Relation Between Malnutrition and the Exocrine Pancreas: A Systematic Review.
J Pediatr Gastroenterol Nutr
February 2018
Objective: The relation between malnutrition and exocrine pancreatic insufficiency (EPI) has been described previously, but it is unclear if malnutrition leads to EPI or vice versa. We systematically synthesized current evidence evaluating the association between malnutrition and EPI in children.
Methods: Pubmed, Embase, and Cochrane databases were searched from inception until February 2017.
Objective: To assess the benefits of pancreatic enzyme replacement therapy (PERT) in children with complicated severe acute malnutrition.
Study Design: We conducted a randomized, controlled trial in 90 children aged 6-60 months with complicated severe acute malnutrition at the Queen Elizabeth Central Hospital in Malawi. All children received standard care; the intervention group also received PERT for 28 days.