Publications by authors named "Debora Sesia"
Lineage switching can induce therapy resistance in cancer. Yet, how lineage fidelity is maintained and how it can be lost remain poorly understood. Here, we have used CRISPR-Cas9-based genetic screening to demonstrate that loss of SMARCB1, a member of the SWI/SNF chromatin remodeling complex, can confer an advantage to clear cell renal cell carcinoma (ccRCC) cells upon inhibition of the renal lineage factor PAX8.
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- - Neuroendocrine prostate cancer (NEPC) often develops from typical prostate cancer following treatments like androgen deprivation therapy, leading to a process called neuroendocrine transdifferentiation that results in tumors with poor survival rates.
- - Researchers analyzed 54 prostate cancer samples over 10 years to differentiate between NE-like tumors and standard adenocarcinoma, identifying specific gene and miRNA expressions that characterize NEPC.
- - A predictive gene expression signature for NEPC was created, highlighting molecular markers that could help enhance diagnosis and treatment options for this challenging cancer subtype.