Publications by authors named "Debora Liliane Souza Reno"
Thioridazine inhibits gene expression control of the cell wall signaling pathway (CWI) in the human pathogenic fungus Paracoccidioides brasiliensis.
Daniela Leite Jabes Ana Claudia de Freitas Oliveira Valquíria Campos Alencar Fabiano Bezerra Menegidio Débora Liliane Souza Reno
Mol Genet Genomics
June 2016
Article Synopsis
- Paracoccidioides brasiliensis is a fungus causing paracoccidioidomycosis (PCM), a prevalent systemic infection in Latin America that often requires long-term treatment and has a high relapse rate.
- Recent research found that thioridazine, a phenothiazine derivative, can effectively inhibit the growth of this fungus in laboratory settings, affecting about 1800 genes involved in its cellular processes.
- The study highlights that thioridazine disrupts the cell wall integrity signaling of the fungus, which could lead to new treatment strategies for fungal infections by targeting the production of essential cell wall components.