A systematic review and functional bioinformatics analysis of genes associated with Crohn's disease identify more than 120 related genes.

Background: Crohn's disease is one of the two categories of inflammatory bowel diseases that affect the gastrointestinal tract. The heritability estimate has been reported to be 0.75.

Multivariate genome-wide association study models to improve prediction of Crohn's disease risk and identification of potential novel variants.

Background: Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) that affects the gastrointestinal tract with diverse symptoms. At present, genome-wide association studies (GWAS) has discovered more than 140 genetic loci associated with CD from several datasets. Using the usual univariate GWAS methods, researchers have discovered common variants with small effects.

A systematic review of genes affecting mitochondrial processes in cancer.

Malignant conversion of cancer cells requires efficient mitochondria reprogramming orchestrated by hundreds of genes. The transformation includes increased energy demand, biosynthesis of precursors, and reactive oxygen species needed to accelerate cell growth, proliferation, and survival. Reprogramming involves complex gene alterations that have not been methodically curated.