Publications by authors named "Debora Comai"
Glyphosate (Gly) is a broad-spectrum herbicide responsible for the inhibition of the enzyme 5-enolpyruvylshikimate-3-phosphate synthase known to be expressed exclusively in plants and not in animals. For decades Gly has been thought to be ineffective in mammals, including humans, until it was demonstrated that rodents treated with the Gly-based herbicide Roundup showed reduced content of neurotransmitters (e.g.
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- CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental condition caused by mutations in the CDKL5 gene, leading to symptoms like early-onset seizures, intellectual disabilities, and visual impairments.
- The study focuses on the role of metabotropic glutamate receptors 5 (mGluR5) in CDD's pathology, indicating that the condition disrupts their function by affecting the binding and localization of the protein Homer1bc, essential for mGluR5 activity.
- Using positive-allosteric-modulators (PAMs) to stimulate mGluR5 in mouse models corrected synaptic and behavioral deficits, suggesting mGluR5 could be a viable target for developing therapies for