Publications by authors named "Debora Call"
Disorders of iron metabolism are largely attributed to an excessive or insufficient expression of hepcidin, the master regulator of systemic iron homeostasis. Here, we investigated whether drugs targeting genetic regulators of hepcidin can affect iron homeostasis. We focused our efforts on drugs approved for clinical use to enable repositioning strategies and/or to reveal iron-related side effects of widely prescribed therapeutics.
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- Hepcidin is a hormone that plays a crucial role in regulating iron levels in the body and is influenced by two main pathways related to iron and inflammation.
- Researchers conducted an RNA interference (RNAi) screen on nearly 20,000 genes in liver cancer cells to discover new factors that can alter hepcidin expression.
- The study identified several key signaling pathways involved in hepcidin regulation, linking its control to liver functions like regeneration and response to nutrients, which could provide insights into conditions like liver injuries and cancer.