Publications by authors named "Debora C C Ramos"
Article Synopsis
- Pyrimethamine, an antimalarial drug, also inhibits crucial enzymes in the leishmanial folate pathway, but requires high concentrations for effectiveness in living organisms.
- Targeted drug formulations, CMD-P and SD-P, were developed to deliver pyrimethamine directly to leishmanial parasites within macrophage cells.
- CMD-P showed promising results by eliminating about 50% of amastigotes with minimal toxicity to host cells, while SD-P was less effective, highlighting the potential for safer leishmaniasis treatments using targeted drug delivery.
