Publications by authors named "Debojit Talukdar"
A self-assembly-directed thixotropic metallohydrogel (i.e., Mg-Tetrakis) of Mg(II)-metal salt and ,,','-tetrakis(2-hydroxy-ethyl)ethylenediamine (i.
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- Ruellia tuberosa L. is a traditional medicinal plant known for its various health benefits, particularly its anti-cancer properties, although the detailed mechanisms behind its effects need further exploration.
- The study aimed to validate the anti-cancer effects of the flower methanolic extract (RTME) specifically against multi-drug resistant triple-negative breast cancer and to investigate the signaling pathways involved.
- Through various assays, the study found that RTME contains multiple phytochemicals that induce cancer cell damage and apoptosis, showing significant cytotoxic effects and inhibiting cancer cell migration.
Article Synopsis
- Malignant tumor cells undergo changes in their shape and gene expression, especially involving cytoskeleton proteins that aid in invasion and spreading to other parts of the body.
- Microtubules, an essential part of the cytoskeleton, depend on posttranslational modifications like acetylation, particularly at lysine 40 on α-tubulin, which is linked to cancer metastasis.
- Noncoding RNAs, including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), play a significant role in regulating the expression of acetylated tubulin, influencing the development and spread of various cancers.
Ethnopharmacological Relevance: Hypericum roeperianum is a medicinal spice traditionally used in West Africa to treat female sterility, fungal infections, and cancer. It has previously been reported that H. roeperianum exhibits cytotoxic potential by reducing the viability of cancer cells involving multidrug-resistant phenotypes, but its underlying molecular mechanism remains unknown.
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