Unbalanced global vaccine product trade pattern: A network perspective.

Mass vaccination is the most cost-effective intervention in response to public health events. Thus, equitable access to vaccine products is essential to ensure global human health. Based on the global vaccine product trade data from 2000 to 2018 and employing social network analysis, this paper explores the unbalanced pattern of global vaccine product trade and assesses the sensitivity interdependence between countries.

Can Nuclear Power Products Mitigate Greenhouse Gas Emissions? Evidence from Global Trade Network.

Since its birth, nuclear power has been a hot topic of academic research while being subject to much controversy. As a new green energy source with zero greenhouse gas (GHG) emissions, nuclear power plays a vital role in combatting global climate change. Based on global databases and various empirical analysis methods, this study aimed to explore the changes in the global nuclear power product trade (GNT) network and its impact on GHG emissions from 2001 to 2018.

Transboundary Water Cooperation in the Post-Cold War Era: Spatial Patterns and the Role of Proximity.

Transboundary water cooperation (TWC) is an important theme of international cooperation. We conducted macro-level research on TWC from the perspective of inter-country relations and constructed a theoretical framework in which multidimensional proximity influences the formation of global TWC. We explained how multidimensional proximity and the constituent elements comprehensively influence the cooperative willingness and ability of actors, which directly drive the generation of global TWC.

Acetaminophen Responsive miR-19b Modulates SIRT1/Nrf2 Signaling Pathway in Drug-Induced Hepatotoxicity.

Previous studies suggest that activation of SIRT1 protects liver from acetaminophen (APAP)-induced injury; however, the detailed mechanism of SIRT1 modulation in this process is still incomplete. Therefore, this study was to investigate the pathophysiological role of SIRT1 in APAP-mediated hepatotoxicity. We found that SIRT1 mRNA and protein were markedly upregulated in human LO2 cells and mouse liver upon APAP exposure.