Publications by authors named "Debilly Berangere"
Article Synopsis
- Subthalamic nucleus deep brain stimulation can improve motor symptoms in Parkinson's disease but may lead to speech and gait issues due to contact balance in electrode positioning.
- A study involving 92 patients analyzed the effects of symmetric versus asymmetric electrode contact balance on speech and axial signs after one year of treatment.
- Results indicate that symmetric settings significantly worsen speech and gait, suggesting a need to avoid such configurations to enhance patient outcomes.
Article Synopsis
- - Patients with multiple system atrophy (MSA) exhibit increased facial movements and muscle tone during sleep compared to those with Parkinson's disease and healthy controls, suggesting a phenomenon called sleep state dissociation.
- - A study analyzed facial muscle activity in 62 individuals (11 with MSA, 38 with Parkinson's, and 13 controls) using video-polysomnography, identifying specific facial movements like frowning and smiling, with "strained face" being notably prominent in MSA patients.
- - The findings indicate that MSA is associated with significant alterations in sleep muscle activity, potentially serving as a key indicator of the condition and its severity, especially during Non-Rapid Eye Movement (NREM) sleep.
Introduction: To investigate glutamatergic metabolism changes in the putamen of patients with de novo Parkinson's Disease (PD) and test the hypothesis that glutamate (Glu) levels are abnormally elevated in the putamen contralateral to where the motor clinical signs predominate as expected from observations in animal models.
Methods: H NMR spectra from 17 healthy control volunteers were compared with spectra from 17 de novo PD patients of who 14 were evaluated again after 2-3 years of disease progression. Statistical analysis used random-effects models.
We investigated whether pre-operative MRI measures of focal brain atrophy could predict cognitive decline occurring after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). For that purpose, we prospectively collected data of 42 consecutive patients with PD who underwent bilateral STN-DBS. Normalized brain structure volumes and cortical thicknesses were measured on pre-operative T1-weighted MRI.
View Article and Find Full Text PDFBackground: Deep brain stimulation (DBS) in Parkinson's disease uses bi-hemispheric high-frequency stimulation within the subthalamus, however, the specific impacts of bilaterality of DBS are still not clear. Thus, we aimed to study the individual-level clinical impact of locations of right-left contact pair-up accounting for each subthalamic nucleus (STN) anatomy.
Methods: Contact locations and effects at 1 year were studied retrospectively in an unselected series of 53 patients operated between 2004 and 2010.
Objectives: Results from preclinical studies suggest that inhibition of glycogen synthase kinase (GSK-3) is a therapeutic option for tauopathies. The aim of the present study was therefore to determine the effects of sodium valproate (VPA), a GSK-3 inhibitor, on disease progression in progressive supranuclear palsy (PSP).
Patients And Methods: We performed a double-blind, randomized, placebo-controlled trial, in 28 PSP patients who received VPA (1500mg/day) or matching placebo for 24 months.
Deep brain stimulation (DBS) is a neurosurgical technique that has now been available for some 25 years. It is used in the treatment of various motor disorders, e.g.
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