Publications by authors named "Debby Boon"
Article Synopsis
- High-risk types of human papillomavirus (hrHPV) cause cervical cancer and some head-and-neck cancers by allowing keratinocytes to grow without anchorage, linked to tumor suppressor gene inactivation.
- The study examined hrHPV-immortalized keratinocytes treated with a drug to reverse DNA methylation, revealing increased silencing of specific microRNAs (miRNAs) connected to anchorage independence in HPV-transformed cells.
- Findings indicate that the methylation of tumor-suppressive miRNAs plays a role in the development of cancer, highlighting their potential as markers for disease and targets for treatment.
Unlabelled: Human papillomavirus 45 (HPV45) is a member of the HPV18-related alpha-7 species and accounts for approximately 5% of all cervical cancer cases worldwide. This study evaluated the genetic diversity of HPV45 and the association of HPV45 variants with the risk of cervical cancer by sequencing the entire E6 and E7 open reading frames of 300 HPV45-positive cervical samples from 36 countries. A total of 43 HPV45 sequence variants were identified that formed 5 phylogenetic sublineages, A1, A2, A3, B1, and B2, the distribution of which varied by geographical region.
View Article and Find Full Text PDFHuman papillomavirus (HPV) 33, a member of the HPV16-related alpha-9 species group, is found in approximately 5% of cervical cancers worldwide. The current study aimed to characterize the genetic diversity of HPV33 and to explore the association of HPV33 variants with the risk for cervical cancer. Taking advantage of the International Agency for Research on Cancer biobank, we sequenced the entire E6 and E7 open reading frames of 213 HPV33-positive cervical samples from 30 countries.
View Article and Find Full Text PDF