Publications by authors named "Debbie X E Lim"
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health issue, prompting a need for accurate preclinical models to study it.
- The liver disease progression aggravation diet (LIDPAD) is a new murine model that mimics human MASLD closely, showing significant similarities in disease features and progression within weeks.
- This model demonstrates responsiveness to dietary changes, making it valuable for researching therapeutic strategies while revealing important interactions between gut health and liver disease.
Objective: Post-surgical peritoneal adhesions are a serious problem for the quality of life and fertility. Yet there are no effective ways of preventing their occurrence. The gap junction protein Cx43 is known to be involved in fibrosis in several different organs and disease conditions often associated with inflammation.
View Article and Find Full Text PDFHigh prevalence of non-healing chronic wounds contributes to a huge healthcare burden across the world. Early treatment interventions for non-healing wounds are vital. It was previously shown that accumulation of 15% or more of senescent cells in a chronic wound edge is an indicator that the wound is unlikely to heal.
View Article and Find Full Text PDFObjective: Intestinal metaplasia (IM) is a premalignant stage that poses a greater risk for subsequent gastric cancer (GC). However, factors regulating IM to GC progression remain unclear. Previously, activated DNA damage response (DDR) signalling factors were shown to engage tumour-suppressive networks in premalignant lesions.
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