Publications by authors named "Debangana Chakravorty"
Peptidyl prolyl isomerases (PPIases) are well-conserved protein-folding enzymes that moonlight as regulators of bacterial virulence. Peptidyl prolyl isomerase A, PPiA (Rv0009) is a secretory protein of Mycobacterium tuberculosis that possesses sequence and structural similarity to eukaryotic cyclophilins. In this study, we validated the interaction of PPiA with stimulator of interferon genes (STING) using both, Escherichia coli-based and mammalian in vitro expression systems.
View Article and Find Full Text PDFMyc is a crucial player in cellular proliferation and a known regulator of cancer pathobiology. Modulation of Myc expression targeting the Myc Protein-Protein Interactors (PPIs) like Myc-Max has till now been the most explored approach. However, this approach threatens the normal cells where Myc expression is required for proliferation.
View Article and Find Full Text PDFBackground: c-Myc plays an important role in cell proliferation, cell growth and in differentiation, making it a key regulator for carcinogenesis and pluripotency. Tight control of c-myc turnover is required by ubiquitin-mediated degradation. This is achieved in the system by two F-box proteins Skp2 and FBXW7.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores how SUMOylation, a post-translational modification process, plays a critical role in cell functions and the maintenance of tissue health, focusing on its involvement in inflammatory bowel diseases (IBD) like Crohn's disease (CD) and ulcerative colitis (UC).
- - In a mouse model of IBD induced by dextran-sulfate-sodium (DSS), researchers found that inflammation led to decreased global SUMOylation in colonic epithelial cells due to a decline in the SUMO E2 enzyme Ubc9, affecting key signaling proteins like Akt1.
- - The researchers also examined human biopsy samples and found similar reductions in Ubc9 and SUMOylated Akt1 in patients
Successful implantation is dependent on the appropriate decidualization of endometrial stromal cells for the establishment of pregnancy in women. Mycobacterial heat shock protein 65 (HSP65) is involved in pathogenesis of the genital tuberculosis (GTB), one of the common causes of infertility in emerging countries. Though implantation failure appears to be the major cause, understanding the status of decidualizaiton process in women diagnosed with GTB has not been thoroughly addressed.
View Article and Find Full Text PDFBackground: Myc is an essential gene having multiple functions such as in cell growth, differentiation, apoptosis, genomic stability, angiogenesis, and disease biology. A large number of researchers dedicated to Myc biology are generating a substantial amount of data in normal and cancer cells/tissues including Burkitt's lymphoma and ovarian cancer.
Results: MYCbase ( http://bicresources.