Normative data stratified for age, education, and gender on the Boston Naming Test.

Stratified normative data for age, education, and gender are provided for the 60-item Boston Naming Test (BNT) on 1026 older participants ages 50-95 years using overlapping age ranges. Tables are presented that convert BNT raw scores to scaled scores and percentiles. Mild dementia cases were eliminated using a comprehensive cognitive battery.

Prevention of noise- and drug-induced hearing loss with D-methionine.

A number of otoprotective agents are currently being investigated. Various types of agents have been found in animal studies to protect against hearing loss induced by cisplatin, carboplatin, aminoglycosides, or noise exposure. For over a decade we have been investigating D-methionine (D-met) as an otoprotective agent.

A longitudinal study of confrontation naming in the "normal" elderly.

The longitudinal effects of age on confrontation naming using the 60-item Boston Naming Test (BNT) were studied in 541 "normal" elderly (ages 50-99). For participants with at least 4 annual assessments (n = 238), 150 were followed for > or =6 years, 81 for > or =8 years, and 43 for > or =10 years. A small practice effect (0.

Glutathione ester but not glutathione protects against cisplatin-induced ototoxicity in a rat model.

Glutathione (GSH) provides an important antioxidant and detoxification pathway. We tested to determine if direct administration of GSH or GSH ester could reduce cisplatin- (CDDP) induced ototoxicity. We tested eight groups of five rats each: a control group, a group receiving 16 mg/kg ip CDDP infused over 30 minutes, and six groups receiving either GSH or GSH ester at 500, 1000, or 1500 mg/kg intraperitoneally 30 minutes prior to 16 mg/kg CDDP.