Publications by authors named "Deanna Dimonte"
J Trauma Acute Care Surg
November 2023
Article Synopsis
- This study investigates the effects of valproic acid (VPA) on outcomes after traumatic brain injury (TBI), proposing that the therapeutic window for administration can be extended to 3 hours with a second dose given later.
- Ten Yorkshire pigs underwent TBI and were assigned to receive either a control treatment or saline with two doses of VPA, the first starting 3 hours post-injury.
- Results showed that VPA-treated animals exhibited less neurological impairment, recovering baseline levels significantly faster, while MRI scans indicated no difference in brain lesion size, confirming the potential of VPA for delayed intervention after TBI.
