Publications by authors named "Deanna C Miller"
Article Synopsis
- The androgen receptor (AR) is a major driver of prostate cancer, and despite new therapies, patients with metastatic disease often have poor outcomes, highlighting the need for deeper understanding of AR-related processes in cancer cells.
- This study uses mass spectrometry to show that increased fatty acyl chain length in phospholipids is a key change in lipid metabolism influenced by AR, particularly focusing on the enzyme ELOVL5 that elongates fatty acids.
- Results indicate that ELOVL5 is crucial for prostate cancer cell proliferation and metastasis, with its depletion causing harmful mitochondrial effects, while supplementation with a fatty acid product of ELOVL5 counteracts these effects, suggesting targeted therapies could focus on lipid elongation pathways.
