Drug use evaluation of moxifloxacin (avelox) using a hand-held electronic device at a canadian teaching hospital.

Background: The use of moxifloxacin (Avelox) has increased at Vancouver General Hospital since its introduction onto the formulary in 2002. It is unclear, however, whether the use of the drug is optimal according to its indication. Hand-held electronic devices, such as personal digital assistants (PDAs), are novel tools that can be used during routine patient care to collect data for drug use evaluation (DUE) reviews.

Moxifloxacin-warfarin interaction: a series of five case reports.

Objective: To report 5 cases of a moxifloxacin-warfarin drug interaction, all resulting in elevated international normalized ratios (INRs) and clinically significant hemorrhage in one case.

Case Summaries: Between January 2002 and January 2004, 4 men and 1 woman (age range 63-92 y) were retrospectively identified as having significantly elevated INR results shortly after being prescribed moxifloxacin with concomitant warfarin therapy.

Discussion: This is the second series of case reports describing an interaction between warfarin and moxifloxacin.