Publications by authors named "Dean G Stathakis"
J Neurochem
December 2011
Article Synopsis
- Dopaminergic neurons are prone to oxidative damage due to high dopamine reactivity, but mutations in the Drosophila gene Catsup increase dopamine levels while also providing resistance to oxidative stress from paraquat.
- Catsup's involvement with key enzymes in dopamine and tetrahydrobiopterin biosynthesis leads to hyperactivation of these enzymes in Catsup mutants, resulting in elevated dopamine levels.
- The presence of excess dopamine suggests that Catsup plays a crucial role in regulating dopamine synthesis and its transport within synaptic vesicles.
